Development and validation of a high-sensitivity assay for measuring p217+tau in plasma.
Alzheimer's disease
biomarker
p212tau
p217tau
phosphorylation
plasma
tau
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
03
2021
revised:
28
04
2021
accepted:
03
05
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Diagnosis of Alzheimer's disease (AD) based on amyloid beta (A), pathologic tau (T), and neurodegeneration (N) biomarkers in peripheral fluids promises to accelerate clinical trials and intercept disease earlier. Qualification of a Simoa plasma p217+tau assay was performed, followed by clinical utility evaluation in a cohort of 227 subjects with broad A and T spectrum. The p217+tau plasma assay was accurate, precise, dilution linear, and highly sensitive. All measured samples were within linear range of the assay, presented higher concentration in AD versus healthy controls ( The assay described here exhibits good technical performance and shows potential as a highly accurate peripheral biomarker for A or T status in AD and cognitively normal subjects.
Identifiants
pubmed: 34095436
doi: 10.1002/dad2.12204
pii: DAD212204
pmc: PMC8158165
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12204Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Déclaration de conflit d'intérêts
G.T.B., S.M., K.V.K., C.T., R.S., M.M., and H.K. are employees of Janssen Research and Development, a pharmaceutical company of Johnson and Johnson.
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