Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
01 Jun 2021
01 Jun 2021
Historique:
received:
19
04
2021
accepted:
11
05
2021
entrez:
7
6
2021
pubmed:
8
6
2021
medline:
8
6
2021
Statut:
epublish
Résumé
Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.
Identifiants
pubmed: 34095685
doi: 10.1021/acsomega.1c01996
pmc: PMC8173612
doi:
Types de publication
Journal Article
Langues
eng
Pagination
13940-13945Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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