Structure-activity relationship of avocadyne.
Animals
Antiviral Agents
/ chemistry
Cell Line, Tumor
Cell Survival
/ drug effects
Fatty Acids
/ metabolism
Humans
Leukemia, Myeloid, Acute
/ drug therapy
Lipid Metabolism
Mice
Mice, SCID
Mitochondria
/ metabolism
Oxidation-Reduction
Persea
/ chemistry
Polyketides
/ chemistry
Stereoisomerism
Structure-Activity Relationship
Journal
Food & function
ISSN: 2042-650X
Titre abrégé: Food Funct
Pays: England
ID NLM: 101549033
Informations de publication
Date de publication:
21 Jul 2021
21 Jul 2021
Historique:
pubmed:
8
6
2021
medline:
1
12
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression.
Identifiants
pubmed: 34095930
doi: 10.1039/d1fo00693b
pmc: PMC8312404
mid: NIHMS1712182
doi:
Substances chimiques
Antiviral Agents
0
Fatty Acids
0
Polyketides
0
avocadyne
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6323-6333Subventions
Organisme : NIAID NIH HHS
ID : R01 AI154860
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK078775
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109907
Pays : United States
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