Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles.
combination therapy
mesoporous silica nanoparticles
osteoporosis
osteostatin
small interfering RNAs
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
12
05
2021
received:
18
03
2021
pubmed:
8
6
2021
medline:
22
1
2022
entrez:
7
6
2021
Statut:
ppublish
Résumé
Nanotechnology changed the concept of treatment for a variety of diseases, producing a huge impact regarding drug and gene delivery. Among the different targeted diseases, osteoporosis has devastating clinical and economic consequences. Since current osteoporosis treatments present several side effects, new treatment approaches are needed. Recently, the application of small interfering RNA (siRNA) has become a promising alternative. Wnt/β-catenin signaling pathway controls bone development and formation. This pathway is negatively regulated by sclerostin, which knock-down through siRNA application would potentially promote bone formation. However, the major bottleneck for siRNA-based treatments is the necessity of a delivery vector, bringing nanotechnology as a potential solution. Among the available nanocarriers, mesoporous silica nanoparticles (MSNs) have attracted great attention for intracellular delivery of siRNAs. The mesoporous structure of MSNs permits the delivery of siRNAs together with another biomolecule, achieving a combination therapy. Here, the effectiveness of a new potential osteoporosis treatment based on MSNs is evaluated. The proposed system is effective in delivering SOST siRNA and osteostatin through systemic injection to bone tissue. The nanoparticle administration produced an increase expression of osteogenic related genes improving the bone microarchitecture. The treated osteoporotic mice recovered values of a healthy situation approaching to osteoporosis remission.
Identifiants
pubmed: 34096198
doi: 10.1002/advs.202101107
pmc: PMC8373152
doi:
Substances chimiques
RNA, Small Interfering
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2101107Subventions
Organisme : European Research Council
ID : 694160
Pays : International
Organisme : Ministerio de Ciencia e Innovación
ID : PID2019-106436RB-I00
Organisme : European Research Council
ID : ERC-2015-AdG
Pays : International
Organisme : European Research Council
ID : VERDI
Pays : International
Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.
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