Treated HIV Infection and Progression of Carotid Atherosclerosis in Rural Uganda: A Prospective Observational Cohort Study.
Anti-HIV Agents
/ therapeutic use
Carotid Artery Diseases
/ diagnostic imaging
Carotid Intima-Media Thickness
Case-Control Studies
Disease Progression
Female
HIV Infections
/ diagnosis
Humans
Longitudinal Studies
Male
Middle Aged
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Uganda
/ epidemiology
Urban Health
HIV infection
Uganda
antiretroviral therapy
atherosclerosis
cardiovascular disease risk
carotid intima media thickness
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
pubmed:
8
6
2021
medline:
3
11
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
Background Although ≈70% of the world's population of people living with HIV reside in sub-Saharan Africa, there are minimal prospective data on the contributions of HIV infection to atherosclerosis in the region. Methods and Results We conducted a prospective observational cohort study of people living with HIV on antiretroviral therapy >40 years of age in rural Uganda, along with population-based comparators not infected with HIV. We collected data on cardiovascular disease risk factors and carotid ultrasound measurements annually. We fitted linear mixed effects models, adjusted for cardiovascular disease risk factors, to estimate the association between HIV serostatus and progression of carotid intima media thickness (cIMT). We enrolled 155 people living with HIV and 154 individuals not infected with HIV and collected cIMT images at 1045 visits during a median of 4 annual visits per participant (interquartile range 3-4, range 1-5). Age (median 50.9 years) and sex (49% female) were similar by HIV serostatus. At enrollment, there was no difference in mean cIMT by HIV serostatus (0.665 versus 0.680 mm,
Identifiants
pubmed: 34096320
doi: 10.1161/JAHA.120.019994
pmc: PMC8477876
doi:
Substances chimiques
Anti-HIV Agents
0
Banques de données
ClinicalTrials.gov
['NCT02445079']
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e019994Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL124712
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW010543
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141053
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113494
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL154863
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132786
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL116275
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062393
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI060354
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG044325
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI145806
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH125667
Pays : United States
Organisme : FIC NIH HHS
ID : K43 TW010715
Pays : United States
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