Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being.
Corynebacterium glutamicum
extremolytes
metabolic engineering
plant phenols
synthetic biology
terpenoids
Journal
Essays in biochemistry
ISSN: 1744-1358
Titre abrégé: Essays Biochem
Pays: England
ID NLM: 0043306
Informations de publication
Date de publication:
26 07 2021
26 07 2021
Historique:
received:
14
03
2021
revised:
26
04
2021
accepted:
27
04
2021
pubmed:
8
6
2021
medline:
7
4
2022
entrez:
7
6
2021
Statut:
ppublish
Résumé
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange flavours, sun blockers, anti-ageing sugars, and polymers for regenerative medicine. Herein, we highlight recent advances in engineering of the microbe into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity.
Identifiants
pubmed: 34096577
pii: 228945
doi: 10.1042/EBC20200134
pmc: PMC8313993
doi:
Substances chimiques
Amino Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
197-212Informations de copyright
© 2021 The Author(s).