Association between preoperative administration of gabapentinoids and 30-day hospital readmission: A retrospective hospital registry study.

Adult Analgesics Boston Hospitals Humans Patient Readmission Pregabalin / adverse effects Registries Retrospective Studies
Complications Gabapentin Gabapentinoids Opioids Postoperative respiratory complications Pregabalin Readmission

Journal

Journal of clinical anesthesia
ISSN: 1873-4529
Titre abrégé: J Clin Anesth
Pays: United States
ID NLM: 8812166

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 02 02 2021
revised: 28 04 2021
accepted: 30 04 2021
pubmed: 8 6 2021
medline: 3 7 2021
entrez: 7 6 2021
Statut: ppublish

Résumé

To evaluate the effectiveness of preoperative gabapentinoid administration. Retrospective hospital registry study. Tertiary referral center (Boston, MA). 111,008 adult non-emergency, non-cardiac surgical patients between 2014 and 2018. Preoperative administration of gabapentinoids (gabapentin or pregabalin). We tested the primary hypothesis that preoperative gabapentinoid use was associated with lower odds of hospital readmission within 30 days. Contingent on this hypothesis, we examined whether lower intraoperative opioid utilization mediated this effect. Secondary outcome was postoperative respiratory complications. Gabapentinoid administration was associated with lower odds of readmission (adjusted odds ratio [OR The preoperative use of pregabalin and gabapentin, up to doses of 75 and 300 mg respectively, mitigates the risks of hospital readmission and postoperative respiratory complications which can in part be explained by lower intraoperative opioid use. Further research is warranted to elucidate mechanisms of the preventive action.

Identifiants

DOI: 10.1016/j.jclinane.2021.110376 PMID: 34098392
pubmed: 34098392
pii: S0952-8180(21)00215-4
doi: 10.1016/j.jclinane.2021.110376
pii:
doi:

Substances chimiques

Analgesics 0
Pregabalin 55JG375S6M

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110376

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Luca J Wachtendorf (LJ)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: lwachten@bidmc.harvard.edu.

Maximilian Sebastian Schaefer (MS)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Duesseldorf University Hospital, Duesseldorf, Germany. Electronic address: msschaef@bidmc.harvard.edu.

Peter Santer (P)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: psanter@bidmc.harvard.edu.

Omid Azimaraghi (O)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: oazimara@bidmc.harvard.edu.

Salameh Sameh Obeidat (SS)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: sobeidat@bidmc.harvard.edu.

Sabine Friedrich (S)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: sa.friedrich91@gmail.com.

Liana Zucco (L)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: lzucco@bidmc.harvard.edu.

Albert Woo (A)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: awoo@bidmc.harvard.edu.

Sarah Nabel (S)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: snabel@bidmc.harvard.edu.

Eswar Sundar (E)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: esundar@bidmc.harvard.edu.

Matthias Eikermann (M)

Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA; Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg-Essen, Essen, Germany. Electronic address: meikermann@montefiore.org.

Satya Krishna Ramachandran (SK)

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: skrama@bidmc.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Association between preoperative...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Association between preoperative...
questionsmedicales.fr › Régions géographiques › Villes › Boston › Association between preoperative...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Hôpitaux › Association between preoperative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association between preoperative...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Réadmission du patient › Association between preoperative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Prégabaline › Association between preoperative...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › Association between preoperative...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Association between preoperative...