A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis.
Animals
Cell Line, Tumor
Cell Movement
Disease Progression
ErbB Receptors
/ metabolism
Female
HEK293 Cells
Humans
In Vitro Techniques
Kaplan-Meier Estimate
Mice
Mice, Nude
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Transplantation
Proteome
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Signal Transduction
Tissue Array Analysis
Ubiquitin
/ metabolism
Wnt Proteins
/ metabolism
Wnt Signaling Pathway
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
13
04
2021
revised:
03
06
2021
accepted:
03
06
2021
pubmed:
9
6
2021
medline:
8
1
2022
entrez:
8
6
2021
Statut:
ppublish
Résumé
Leucine-rich repeat-containing G protein-coupled receptors 4, 5, and 6 (LGR4/5/6) play critical roles in development and cancer. The widely accepted mechanism is that these proteins, together with their R-spondin ligands, stabilize Wnt receptors, thus potentiating Wnt signaling. Here we show that LGR4 enhanced breast cancer cell metastasis even when Wnt signaling was deactivated pharmacologically or genetically. Furthermore, LGR4 mutants that cannot potentiate Wnt signaling nevertheless promoted breast cancer cell migration and invasion
Identifiants
pubmed: 34099494
pii: 0008-5472.CAN-21-1112
doi: 10.1158/0008-5472.CAN-21-1112
pmc: PMC8416783
mid: NIHMS1714580
doi:
Substances chimiques
LGR4 protein, human
0
Proteome
0
Receptors, G-Protein-Coupled
0
Ubiquitin
0
Wnt Proteins
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4441-4454Subventions
Organisme : NCI NIH HHS
ID : R01 CA204926
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIH HHS
ID : S10 OD028648
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA203690
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA186784
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2021 American Association for Cancer Research.
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