GPR120 signaling controls amyloid-β degrading activity of matrix metalloproteinases.
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
04 Jun 2021
04 Jun 2021
Historique:
received:
07
10
2020
revised:
16
05
2021
accepted:
26
05
2021
entrez:
8
6
2021
pubmed:
9
6
2021
medline:
9
6
2021
Statut:
aheadofprint
Résumé
Alzheimer disease (AD) is characterized by the extensive deposition of amyloid-β peptide (Aβ) in the brain. Brain Aβ level is regulated by a balance between Aβ production and clearance. The clearance rate of Aβ is decreased in the brains of sporadic AD patients, indicating that the dysregulation of Aβ clearance mechanisms affects the pathological process of AD. Astrocytes are among the most abundant cells in the brain and are implicated in the clearance of brain Aβ via their regulation of the blood-brain barrier, glymphatic system, and proteolytic degradation. The cellular morphology and activity of astrocytes are modulated by several molecules, including ω3 polyunsaturated fatty acids, such as docosahexaenoic acid, which is one of the most abundant lipids in the brain, via the G protein-coupled receptor GPR120/FFAR4. In this study, we analyzed the role of GPR120 signaling in the Aβ-degrading activity of astrocytes. Treatment with the selective antagonist upregulated the matrix metalloproteinase (MMP) inhibitor-sensitive Aβ-degrading activity in primary astrocytes. Moreover, the inhibition of GPR120 signaling increased the levels of
Identifiants
pubmed: 34099509
pii: JNEUROSCI.2595-20.2021
doi: 10.1523/JNEUROSCI.2595-20.2021
pmc: PMC8276734
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032990
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080820
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046139
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG017216
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018023
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003949
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG025711
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
Déclaration de conflit d'intérêts
All authors declare no competing financial interest.
Références
J Neurosci. 2005 Jan 12;25(2):436-45
pubmed: 15647487
Cell. 2019 Nov 27;179(6):1289-1305.e21
pubmed: 31761534
Oncotarget. 2016 Aug 2;7(31):49961-49971
pubmed: 27363023
Science. 2010 Dec 24;330(6012):1774
pubmed: 21148344
EMBO Mol Med. 2018 Mar;10(3):
pubmed: 29311134
Nature. 2007 Jun 14;447(7146):869-74
pubmed: 17568749
Biochem Biophys Res Commun. 1994 Dec 30;205(3):1755-61
pubmed: 7811262
Cell Mol Life Sci. 2019 Aug;76(16):3207-3228
pubmed: 31172215
J Cell Biochem. 2017 Dec;118(12):4183-4190
pubmed: 28488760
Nat Rev Neurosci. 2014 Dec;15(12):771-85
pubmed: 25387473
Int Immunol. 2019 Aug 23;31(9):559-567
pubmed: 30772915
Nutrients. 2017 Aug 25;9(9):
pubmed: 28841192
Gene. 2013 Mar 15;517(1):12-8
pubmed: 23313877
Biochemistry. 1999 Aug 31;38(35):11570-6
pubmed: 10471309
J Lipid Res. 1965 Oct;6(4):537-44
pubmed: 5865382
Biochim Biophys Acta. 2011 Feb;1812(2):213-9
pubmed: 20674741
Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2025-30
pubmed: 9050898
J Neuroinflammation. 2017 Apr 26;14(1):91
pubmed: 28446241
Nature. 2012 Feb 19;483(7389):350-4
pubmed: 22343897
Nature. 2012 Aug 2;488(7409):96-9
pubmed: 22801501
Cell. 2012 May 11;149(4):886-98
pubmed: 22579289
EMBO J. 2011 Oct 14;30(23):4815-24
pubmed: 22002539
Nat Med. 2014 Aug;20(8):942-7
pubmed: 24997608
PLoS One. 2011 Jan 05;6(1):e15816
pubmed: 21246057
BMC Genomics. 2013 Nov 25;14:831
pubmed: 24274089
Biochemistry. 2010 Feb 16;49(6):1127-36
pubmed: 20050683
Mol Pharmacol. 2012 May;81(5):631-42
pubmed: 22282525
J Immunol. 2019 Feb 1;202(3):747-759
pubmed: 30598514
J Biol Chem. 2009 Oct 16;284(42):28917-25
pubmed: 19692707
Brain Res. 2015 Feb 9;1597:220-46
pubmed: 25498862
Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3
pubmed: 24881566
PLoS One. 2014 Feb 27;9(2):e89605
pubmed: 24586907
FASEB J. 2020 Jun;34(6):7661-7674
pubmed: 32307772
Front Aging Neurosci. 2016 Jul 05;8:160
pubmed: 27458370
J Biol Chem. 2001 Jun 15;276(24):21895-901
pubmed: 11278416
J Biol Chem. 2001 Dec 21;276(51):47863-8
pubmed: 11604391
Nat Genet. 2002 Sep;32(1):107-8
pubmed: 12145662
J Biol Chem. 1998 Dec 4;273(49):32730-8
pubmed: 9830016
Arch Neurol. 2003 Jul;60(7):940-6
pubmed: 12873849
J Neurochem. 2006 Jan;96(2):385-95
pubmed: 16300635
Biochem Biophys Res Commun. 2007 Mar 9;354(2):591-7
pubmed: 17250804
Mol Pharmacol. 2017 Jun;91(6):630-641
pubmed: 28385906
J Biol Chem. 2015 Jun 12;290(24):15163-74
pubmed: 25918154
J Biol Chem. 1995 Apr 21;270(16):9564-70
pubmed: 7721886
Sci Data. 2018 Sep 11;5:180185
pubmed: 30204156
J Neurosci Res. 2008 Aug 15;86(11):2499-504
pubmed: 18449948
Nat Rev Drug Discov. 2016 Mar;15(3):161-72
pubmed: 26822831
Mol Neurobiol. 2019 Apr;56(4):2685-2702
pubmed: 30054857
J Neurochem. 2007 Jan;100(2):458-67
pubmed: 17241160
Adv Biol Regul. 2017 May;64:33-38
pubmed: 28082052
Neurobiol Dis. 2016 Jul;91:37-46
pubmed: 26921472
Sci Data. 2016 Oct 11;3:160089
pubmed: 27727239
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):165-72
pubmed: 20207120
Trends Pharmacol Sci. 2017 Sep;38(9):809-821
pubmed: 28734639
Cold Spring Harb Perspect Med. 2012 Jun;2(6):a006379
pubmed: 22675659
J Neurochem. 2008 May;105(3):584-94
pubmed: 18042177
Neuroreport. 1999 Sep 29;10(14):2965-9
pubmed: 10549806
FEBS Lett. 1996 Nov 4;396(2-3):139-42
pubmed: 8914975
Nat Med. 2005 Jan;11(1):90-4
pubmed: 15619630
Hum Mol Genet. 2016 Jul 15;25(14):2948-2958
pubmed: 27179792
Cell Mol Life Sci. 2019 Aug;76(16):3167-3191
pubmed: 31197405
J Neuroinflammation. 2016 Mar 10;13(1):61
pubmed: 26965310
J Cell Physiol. 2005 May;203(2):345-52
pubmed: 15468069
Neuroreport. 1996 Sep 2;7(13):2163-6
pubmed: 8930981
Mol Psychiatry. 2020 Jun 5;:
pubmed: 32504049
RNA. 2003 Apr;9(4):493-501
pubmed: 12649500
Cell. 2010 Sep 3;142(5):687-98
pubmed: 20813258
Hum Mol Genet. 2004 Jan 15;13(2):159-70
pubmed: 14645205
J Biol Chem. 2006 Aug 25;281(34):24566-74
pubmed: 16787929