Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway.
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dermis
/ cytology
Ginsenosides
/ pharmacology
Glycogen Synthase Kinase 3 beta
/ metabolism
Hair
/ drug effects
Hair Follicle
/ cytology
Humans
Phosphatidylinositol 3-Kinases
/ metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
/ drug effects
Spheroids, Cellular
Wnt Proteins
/ metabolism
beta Catenin
/ metabolism
AKT
Ginsenoside Rg4
dermal papilla
hair growth property
β-catenin
Journal
Journal of microbiology and biotechnology
ISSN: 1738-8872
Titre abrégé: J Microbiol Biotechnol
Pays: Korea (South)
ID NLM: 9431852
Informations de publication
Date de publication:
28 Jul 2021
28 Jul 2021
Historique:
received:
26
01
2021
revised:
27
05
2021
accepted:
29
05
2021
pubmed:
9
6
2021
medline:
10
11
2021
entrez:
8
6
2021
Statut:
ppublish
Résumé
Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities including antioxidant and anti-inflammatory properties in several cell types. The purpose of this study was to use an in vivo model of hair follicle (HF)-mimic based on a human dermal papilla (DP) spheroid system prepared by three-dimensional (3D) culture and to investigate the effect of Rg4 on the hair-inductive properties of DP cells. Treatment of the DP spheroids with Rg4 (20 to 50 μg/ml) significantly increased the viability and size of the DP spheres in a dose-dependent manner. Rg4 also increased the mRNA and protein expression of DP signature genes that are related to hair growth including
Identifiants
pubmed: 34099599
pii: jmb.2101.01032
doi: 10.4014/jmb.2101.01032
pmc: PMC9706015
doi:
Substances chimiques
Ginsenosides
0
Wnt Proteins
0
beta Catenin
0
ginsenoside Rg4
126223-28-7
Glycogen Synthase Kinase 3 beta
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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