Tumor suppressor p53 regulates intestinal type 2 immunity.
Animals
Cell Line, Tumor
Eosinophils
/ immunology
Gene Expression Regulation
Goblet Cells
/ immunology
Host-Parasite Interactions
/ immunology
Humans
Immunity, Innate
/ immunology
Intestine, Small
/ immunology
Intestines
/ immunology
Membrane Proteins
/ genetics
Mice, Inbred C57BL
Mice, Knockout
Nippostrongylus
/ immunology
Parasitic Diseases
/ immunology
Tritrichomonas
/ immunology
Tumor Suppressor Protein p53
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 06 2021
07 06 2021
Historique:
received:
02
09
2020
accepted:
30
04
2021
entrez:
8
6
2021
pubmed:
9
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca
Identifiants
pubmed: 34099671
doi: 10.1038/s41467-021-23587-x
pii: 10.1038/s41467-021-23587-x
pmc: PMC8184793
doi:
Substances chimiques
Lrmp protein, mouse
0
Membrane Proteins
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3371Subventions
Organisme : NCI NIH HHS
ID : R01 CA260837
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227912
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA072720
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA160558
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214746
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203965
Pays : United States
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