Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health.
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
23
11
2020
accepted:
19
04
2021
pubmed:
9
6
2021
medline:
4
9
2021
entrez:
8
6
2021
Statut:
ppublish
Résumé
Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves mid-life metabolic health in animal models. However, with transition to industrialised food systems, reduced dietary protein is associated with poor health outcomes in humans. Here we systematically interrogate the impact of carbohydrate quality in diets with varying carbohydrate and protein content. Studying 700 male mice on 33 isocaloric diets, we find that the type of carbohydrate and its digestibility profoundly shape the behavioural and physiological responses to protein dilution, modulate nutrient processing in the liver and alter the gut microbiota. Low (10%)-protein, high (70%)-carbohydrate diets promote the healthiest metabolic outcomes when carbohydrate comprises resistant starch (RS), yet the worst outcomes were with a 50:50 mixture of monosaccharides fructose and glucose. Our findings could explain the disparity between healthy, high-carbohydrate diets and the obesogenic impact of protein dilution by glucose-fructose mixtures associated with highly processed diets.
Identifiants
pubmed: 34099926
doi: 10.1038/s42255-021-00393-9
pii: 10.1038/s42255-021-00393-9
doi:
Substances chimiques
Dietary Carbohydrates
0
Dietary Proteins
0
Starch
9005-25-8
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
810-828Références
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