Effectiveness of two rehabilitation treatments in the modulation of inflammation during the acute phase in patients with knee prostheses and assessment of the role of the diet in determining post-surgical inflammation.
C-reactive protein (CRP)
Erythrosedimentation rate (ESR)
MEDIET Questionnaire
Over knee oedema (EDO)
Total knee aerthroplasty (TKA)
Under knee oedema (EDU)
Journal
Journal of orthopaedics
ISSN: 0972-978X
Titre abrégé: J Orthop
Pays: India
ID NLM: 101233220
Informations de publication
Date de publication:
Historique:
received:
01
04
2021
accepted:
09
05
2021
entrez:
8
6
2021
pubmed:
9
6
2021
medline:
9
6
2021
Statut:
epublish
Résumé
NCT04580069. Total knee arthroplasty is associated with an elevated inflammatory response both at a local and systemic level. The main objective of this study is to demonstrate the effectiveness of lymphatic drainage and connective tissue techniques in modulating systemic inflammation. Another objective is to evaluate the existence, at baseline, of a correlation between the inflammation indices and the level of adherence to the Mediterranean diet. 34 patients were recruited, and divided into three groups. The control group followed the normal rehabilitation protocol. The other two groups were subjected, in addition to the standard treatment, to manual lymphatic drainage treatment or connective tissue techniques. The outcomes were recorded in three stages: upon entering the hospital, 1 week after entry and at follow-up 21 days after surgery. The results of the study showed that both methods, compared with the standard treatment only, positively influenced the final outcomes. In regard to the systemic inflammation, lymphatic drainage and connective techniques showed equal efficacy and similar timing in modulating ESR, while they differ in how they affect CRP. With regard to the local inflammation, the effectiveness of both methods was confirmed with some differences in the location. Finally, analysis of the correlation between inflammatory T0 indices and adherence to the Mediterranean diet showed that patients with higher adhesion index have on average lower PCR, EDO and EDU values. The post-surgical inflammatory pattern can be positively modified by the rehabilitation methods analyzed, albeit with different methodologies and timing.The influence of the diet on inflammatory parameters, although less evident, seems to show encouraging results worth of further studies.
Sections du résumé
CLINICAL TRIAL NUMBER
BACKGROUND
NCT04580069.
BACKGROUND
BACKGROUND
Total knee arthroplasty is associated with an elevated inflammatory response both at a local and systemic level. The main objective of this study is to demonstrate the effectiveness of lymphatic drainage and connective tissue techniques in modulating systemic inflammation. Another objective is to evaluate the existence, at baseline, of a correlation between the inflammation indices and the level of adherence to the Mediterranean diet.
METHODS
METHODS
34 patients were recruited, and divided into three groups. The control group followed the normal rehabilitation protocol. The other two groups were subjected, in addition to the standard treatment, to manual lymphatic drainage treatment or connective tissue techniques. The outcomes were recorded in three stages: upon entering the hospital, 1 week after entry and at follow-up 21 days after surgery.
RESULTS
RESULTS
The results of the study showed that both methods, compared with the standard treatment only, positively influenced the final outcomes. In regard to the systemic inflammation, lymphatic drainage and connective techniques showed equal efficacy and similar timing in modulating ESR, while they differ in how they affect CRP. With regard to the local inflammation, the effectiveness of both methods was confirmed with some differences in the location. Finally, analysis of the correlation between inflammatory T0 indices and adherence to the Mediterranean diet showed that patients with higher adhesion index have on average lower PCR, EDO and EDU values.
CONCLUSIONS
CONCLUSIONS
The post-surgical inflammatory pattern can be positively modified by the rehabilitation methods analyzed, albeit with different methodologies and timing.The influence of the diet on inflammatory parameters, although less evident, seems to show encouraging results worth of further studies.
Identifiants
pubmed: 34099953
doi: 10.1016/j.jor.2021.05.016
pii: S0972-978X(21)00124-0
pmc: PMC8165292
doi:
Banques de données
ClinicalTrials.gov
['NCT04580069']
Types de publication
Journal Article
Langues
eng
Pagination
237-243Informations de copyright
© 2021 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.
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