The pleiotropic effects of Prunus avium L. extract against oxidative stress on human fibroblasts. An in vitro approach.
Antioxidants
/ adverse effects
Cell Line
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cellular Senescence
/ drug effects
Fibroblasts
/ drug effects
Fruit
/ chemistry
Gene Expression
/ drug effects
Humans
Hydrogen Peroxide
/ pharmacology
Oxidative Stress
/ drug effects
Plant Extracts
/ adverse effects
Prunus avium
/ chemistry
Skin
/ cytology
Skin Care
/ methods
Antioxidant
Dermal fibroblasts
In vitro
Natural extract
Skin biology
Sweet cherry
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
13
02
2021
accepted:
01
06
2021
pubmed:
9
6
2021
medline:
31
12
2021
entrez:
8
6
2021
Statut:
ppublish
Résumé
There is a persistent interest in innovative and multifunctional ingredients in biology research. With regards to this, natural sources have an important role due to their multiple benefits. Thus, this study aims to present the pleiotropic activity of Prunus avium L. extract on human primary fibroblasts for proving its efficacy in dermis-related processes. We focused on the safety and efficacy assessments based on cytotoxicity and gene expression analysis under oxidative stress. Specifically, Prunus avium L. extract was proved non-cytotoxic in human fibroblasts. The gene expression analysis unveiled that this extract has in vitro protective properties on human dermal fibroblasts under oxidative stress related to antioxidant activity, anti-inflammatory response, cell proliferation and cell- aging. Our study demonstrated for the very first time that the Prunus avium L. extract is a multifunctional ingredient as it mediates several human dermis-related in vitro processes highlighting its potential to be used as an active ingredient in skin care products.
Identifiants
pubmed: 34100152
doi: 10.1007/s11033-021-06464-0
pii: 10.1007/s11033-021-06464-0
doi:
Substances chimiques
Antioxidants
0
Plant Extracts
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4441-4448Subventions
Organisme : Foundation for Research and Technology-Hellas
ID : 148
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