Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons.
cell migration
cerebellum
cytokinesis
developmental biology
mouse
neuroscience
semaphorins
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 06 2021
08 06 2021
Historique:
received:
29
06
2020
accepted:
07
06
2021
pubmed:
9
6
2021
medline:
30
11
2021
entrez:
8
6
2021
Statut:
epublish
Résumé
Plexin-B2 deletion leads to aberrant lamination of cerebellar granule neurons (CGNs) and Purkinje cells. Although in the cerebellum Plexin-B2 is only expressed by proliferating CGN precursors in the outer external granule layer (oEGL), its function in CGN development is still elusive. Here, we used 3D imaging, in vivo electroporation and live-imaging techniques to study CGN development in novel cerebellum-specific
Identifiants
pubmed: 34100719
doi: 10.7554/eLife.60554
pii: 60554
pmc: PMC8211449
doi:
pii:
Substances chimiques
Nerve Tissue Proteins
0
Plxnb2 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Van Battum et al.
Déclaration de conflit d'intérêts
EV, CH, YZ, SF, AC No competing interests declared, RK Reviewing editor, eLife
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