Mitochondrial DNA haplogroups and domain-specific neurocognitive performance in adults with HIV.
African Americans
DNA
HIV
Hispanic Americans
Mitochondrial
Neurocognitive disorders
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
23
09
2020
accepted:
16
05
2021
revised:
14
04
2021
pubmed:
9
6
2021
medline:
1
2
2022
entrez:
8
6
2021
Statut:
ppublish
Résumé
Neurocognitive (NC) impairment (NCI) is an important cause of morbidity in persons with HIV (PWH). In the high-energy environment of the central nervous system, mitochondria contribute to neuroinflammation and aging, which may ultimately drive the pathogenesis of neurodegenerative diseases. Mitochondrial DNA (mtDNA) haplogroups are associated with health outcomes in PWH. For example, we previously observed less global NCI in Hispanic ancestry PWH having mtDNA haplogroup B. Another study reported increased NCI among PWH having African subhaplogroup L2a. We therefore analyzed NC domains in relation to these haplogroups in CNS HIV Antiretroviral Therapy Effects Research (CHARTER), a multi-site observational neuro-HIV study. Haplogroups were assigned using mtDNA sequence in 1016 PWH. Outcomes were NCI, defined by domain deficit score and mean T-scores (TS) for seven NC domains. Ancestry-stratified analyses of NC performance included Wilcoxon rank sum, χ
Identifiants
pubmed: 34101088
doi: 10.1007/s13365-021-00989-7
pii: 10.1007/s13365-021-00989-7
pmc: PMC8527871
mid: NIHMS1741638
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
557-567Subventions
Organisme : NIMH NIH HHS
ID : K24 MH097673
Pays : United States
Organisme : NIMH NIH HHS
ID : HHSN271201000030C
Pays : United States
Organisme : NIMH NIH HHS
ID : HHSN271201000036C
Pays : United States
Organisme : NIMH NIH HHS
ID : N01MH22005
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
Organisme : NIMH NIH HHS
ID : N01 MH022005
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107345
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095621
Pays : United States
Informations de copyright
© 2021. Journal of NeuroVirology, Inc.
Références
J Neurol. 2017 Aug;264(8):1715-1727
pubmed: 28567537
Am J Med Genet. 1999 Jul 2;85(1):20-30
pubmed: 10377009
Neuron. 2019 May 8;102(3):683-693.e4
pubmed: 30871859
Genomics. 1993 Jul;17(1):171-84
pubmed: 8104867
J Alzheimers Dis. 2010;20 Suppl 2:S369-79
pubmed: 20463396
Front Neurosci. 2018 Oct 12;12:682
pubmed: 30369864
Pathog Immun. 2016 Fall-Winter;1(2):330-351
pubmed: 28317034
Clin Infect Dis. 2015 Nov 1;61(9):1476-84
pubmed: 26129753
J Clin Exp Neuropsychol. 2011 Jun;33(5):505-22
pubmed: 21391011
Hum Mutat. 2011 Jan;32(1):25-32
pubmed: 20960467
Toxicol Pathol. 2014 Jul;42(5):811-22
pubmed: 24067671
Ann N Y Acad Sci. 2008 Dec;1147:1-20
pubmed: 19076426
Hum Genet. 2014 Jul;133(7):861-8
pubmed: 24488180
Front Aging Neurosci. 2016 Dec 08;8:298
pubmed: 28008314
Ann Epidemiol. 2017 Apr;27(4):238-243
pubmed: 28325538
J Neurovirol. 2011 Feb;17(1):3-16
pubmed: 21174240
BMC Bioinformatics. 2011 Oct 19;12:402
pubmed: 22011106
Brain Behav Immun. 2015 Mar;45:1-12
pubmed: 25449672
Neurology. 2007 Oct 30;69(18):1789-99
pubmed: 17914061
AIDS Rev. 2013 Oct-Dec;15(4):213-20
pubmed: 24322381
J Clin Invest. 2013 Apr;123(4):1405-12
pubmed: 23543062
Neurotox Res. 2017 Nov;32(4):723-733
pubmed: 28695547
Int Rev Neurobiol. 2019;145:29-65
pubmed: 31208526
Neurosci Lett. 2004 Jul 15;365(1):28-32
pubmed: 15234467
Clin Neuropsychol. 2012;26(6):894-908
pubmed: 22708483
Hum Mol Genet. 2010 Sep 1;19(17):3343-53
pubmed: 20566709
Lancet Infect Dis. 2013 Nov;13(11):976-86
pubmed: 24156898
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6892-5
pubmed: 7624338
PLoS One. 2016 Oct 6;11(10):e0163772
pubmed: 27711166
Neurology. 2010 Dec 7;75(23):2087-96
pubmed: 21135382
PLoS One. 2010 Aug 06;5(8):e12037
pubmed: 20700462
Nat Genet. 1999 Oct;23(2):147
pubmed: 10508508