Efficacy of 1 versus 3 days of intravenous amikacin as a prophylaxis for patients undergoing transurethral resection of the prostate: A prospective randomized trial.
Journal
Indian journal of urology : IJU : journal of the Urological Society of India
ISSN: 0970-1591
Titre abrégé: Indian J Urol
Pays: India
ID NLM: 8510441
Informations de publication
Date de publication:
Historique:
received:
05
09
2020
revised:
03
11
2020
accepted:
13
02
2021
entrez:
9
6
2021
pubmed:
10
6
2021
medline:
10
6
2021
Statut:
ppublish
Résumé
There are no uniform guidelines on the duration of antibiotic prophylaxis for transurethral resection of the prostate (TURP). The objective of this study was to evaluate the efficacy of 1 day versus 3 days of intravenous amikacin as prophylaxis, before TURP. In this prospective randomized control trial, patients with sterile preoperative urine culture were randomized to receive either 1 day (Group A) or 3 days (Group B) of intravenous (IV) amikacin. All patients had their catheter removed on the 3 Of the 338 patients randomized, 314 patients were evaluable until day 7 and 307 until 1 month. Bacteriuria rate at day 4 (Group A: 8.8% [95% confidence interval (CI): 4.2-13.2]; Group B: 4.4% [95% CI: 1.2%-7.7%], One day is possibly noninferior to 3 days of IV amikacin as prophylaxis in patients undergoing TURP with respect to bacteriuria and symptomatic UTI, with an added advantage of lower antibiotic resistance.
Identifiants
pubmed: 34103795
doi: 10.4103/iju.IJU_494_20
pii: IJU-37-133
pmc: PMC8173930
doi:
Types de publication
Journal Article
Langues
eng
Pagination
133-139Informations de copyright
Copyright: © 2021 Indian Journal of Urology.
Déclaration de conflit d'intérêts
Conflicts of interest: There are no conflicts of interest.
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