Inclusion of microbe-derived antioxidant during pregnancy and lactation attenuates high-fat diet-induced hepatic oxidative stress, lipid disorders, and NLRP3 inflammasome in mother rats and offspring.
NLRP3 inflammasome
high-fat diet
liver
microbe-derived antioxidant
rats
Journal
Food & nutrition research
ISSN: 1654-661X
Titre abrégé: Food Nutr Res
Pays: Sweden
ID NLM: 101488795
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
04
2019
revised:
15
07
2019
accepted:
16
07
2019
entrez:
9
6
2021
pubmed:
23
8
2019
medline:
23
8
2019
Statut:
epublish
Résumé
This study aimed to evaluate the effects of microbe-derived antioxidant (MA) on high-fat diet (HFD)-induced hepatic lipid disorders in mother rats and offspring. A total of 36 female rats were randomly divided into three groups at the beginning of pregnancy: the control group (CG), HFD, and HFD with 2% MA. Mother rats were slaughtered at the first and 10th day of lactation (L1 and L10) and offspring were slaughtered at L10. The plasma and liver of mother rats, and liver of offspring were collected. The results showed that MA reversed HFD-induced activities of inducible nitric oxide synthase (iNOS) and antioxidative enzymes in liver of mother rats and offspring. In addition, MA reduced HFD-induced lipid accumulation through decreasing the low-density lipoprotein cholesterol (LDLC) content in plasma of mother rats and improving hepatic fatty acid synthase (FAS) in mother rats and offspring. MA decreased HFD-induced hepatic alkaline phosphatase (AKP) activity in liver of mother rats and offspring. Furthermore, MA reduced HFD-activated nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in liver of mother rats and offspring. MA supplementation reversed HFD-induced hepatic oxidative stress, lipid accumulation, NLRP3 inflammasome, and function in mother rats and offspring, suggesting MA can be functional ingredients to improve maternal-fetal health.
Identifiants
pubmed: 34104129
doi: 10.29219/fnr.v63.3504
pii: 3504
pmc: PMC8153845
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2019 Zhen Luo et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest in relation to this work.
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