The influence of RS738409 I148M polymorphism of patatin-like phospholipase domain containing 3 gene on the susceptibility of non-alcoholic fatty liver disease.
Adult
Blood Glucose
Body Mass Index
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Lipase
/ genetics
Liver Function Tests
Male
Membrane Proteins
/ genetics
Middle Aged
Non-alcoholic Fatty Liver Disease
/ genetics
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Turkey
/ epidemiology
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
14 May 2021
14 May 2021
Historique:
received:
15
06
2020
accepted:
21
04
2021
entrez:
9
6
2021
pubmed:
10
6
2021
medline:
23
6
2021
Statut:
ppublish
Résumé
We aimed to elucidate the frequency of polymorphic genotypes and alleles of patatin-like phospholipase domain containing 3 rs738409 polymorphism and its possible associations with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis in a cohort from Turkey.We enrolled 200 patients diagnosed with NAFLD and genotyped for rs738409 I148M polymorphism by real-time polymerase chain reaction, particularly by melting curve analysis. SPSS analysis software was used for statistical significance. Continuous variable values were expressed as mean ± standard deviation. Significant statistical level was chosen as p = 0.05.Our results demonstrate in a cohort from Turkey that rs738409 C > G polymorphism (I148M) of patatin-like phospholipase domain containing 3 gene is significantly able to affect individuals to have NAFLD in unadjusted regression model.Consistent with the previous studies in other populations, our study group showed a significantly higher risk of having NAFLD in unadjusted regression model but not in the adjusted model indicating that non-genetic factors such as age and sex may be responsible for the association. However, independent studies need to validate our findings with a larger group of NAFLD patients, as well as in different ethnic cohorts.
Identifiants
pubmed: 34106646
doi: 10.1097/MD.0000000000025893
pii: 00005792-202105140-00066
pmc: PMC8133255
doi:
Substances chimiques
Blood Glucose
0
Membrane Proteins
0
Lipase
EC 3.1.1.3
adiponutrin, human
EC 3.1.1.3
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25893Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no funding and conflicts of interest to disclose.
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