Deletion of TLR2
EMP
TLR2
embryo
hematopoiesis
lethality
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
29
04
2021
received:
18
12
2020
accepted:
08
06
2021
pubmed:
10
6
2021
medline:
17
11
2021
entrez:
9
6
2021
Statut:
ppublish
Résumé
Early embryonic hematopoiesis in mammals is defined by three successive waves of hematopoietic progenitors which exhibit a distinct hematopoietic potential and provide continuous support for the development of the embryo and adult organism. Although the functional importance of each of these waves has been analyzed, their spatio-temporal overlap and the lack of wave-specific markers hinders the accurate separation and assessment of their functional roles during early embryogenesis. We have recently shown that TLR2, in combination with c-kit, represents the earliest signature of emerging precursors of the second hematopoietic wave, erythro-myeloid precursors (EMPs). Since the onset of Tlr2 expression distinguishes EMPs from primitive progenitors which coexist in the yolk sac from E7.5, we generated a novel transgenic "knock in" mouse model, Tlr2
Identifiants
pubmed: 34107067
doi: 10.1002/eji.202049142
doi:
Substances chimiques
Tlr2 protein, mouse
0
Toll-Like Receptor 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2237-2250Informations de copyright
© 2021 Wiley-VCH GmbH.
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