Neuronal and glial cell number is altered in a cortical layer-specific manner in autism.
anatomy
autism
cerebral cortex
postmortem
Journal
Autism : the international journal of research and practice
ISSN: 1461-7005
Titre abrégé: Autism
Pays: England
ID NLM: 9713494
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
pubmed:
11
6
2021
medline:
28
9
2021
entrez:
10
6
2021
Statut:
ppublish
Résumé
The cerebral cortex affected with autism spectrum disorder presents changes in the number of neurons and glia cells, possibly leading to a dysregulation of brain circuits and affecting behavior. However, little is known about cell number alteration in specific layers of the cortex in autism spectrum disorder. We found an increase in the number of neurons and a decrease in the number of astrocytes in specific layers of the prefrontal cortex in postmortem human brains from autism spectrum disorder cases. We hypothesize that this may be due to a failure in neural stem cells to shift differentiation from neurons to glial cells during prenatal brain development. These data provide key anatomical findings that contribute to the bases of autism spectrum disorder pathogenesis.
Identifiants
pubmed: 34107793
doi: 10.1177/13623613211014408
pmc: PMC9762515
mid: NIHMS1694103
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2238-2253Subventions
Organisme : NIMH NIH HHS
ID : R01 MH094681
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107131
Pays : United States
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