Synthetic extracellular volume fraction without hematocrit sampling for hepatic applications.
Extracellular volume fraction
Hematocrit
Liver fibrosis
Magnetic resonance imaging
Journal
Abdominal radiology (New York)
ISSN: 2366-0058
Titre abrégé: Abdom Radiol (NY)
Pays: United States
ID NLM: 101674571
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
03
01
2021
accepted:
22
05
2021
revised:
03
05
2021
pubmed:
11
6
2021
medline:
21
9
2021
entrez:
10
6
2021
Statut:
ppublish
Résumé
Calculation of extracellular volume fraction (ECV) currently receives increasing interest as a potential biomarker for non-invasive assessment of liver fibrosis. ECV calculation requires hematocrit (Hct) sampling, which might be difficult to obtain in a high-throughput radiology department. The aim of this study was to generate synthetic ECV for hepatic applications without the need for Hct sampling. In this prospective study participants underwent liver MRI. T1 mapping was performed before and after contrast administration. Blood Hct was obtained prior to MRI. We hypothesized that the relationship between Hct and longitudinal relaxation rate of blood (R1 = 1/T1 180 consecutive patients were divided into derivation (n = 90) and validation (n = 90) cohorts. In the derivation cohort, native R1 Synthetic ECV seems to offer an alternative method for non-invasive quantification of the hepatic ECV. It may potentially overcome an important barrier to clinical implementation of ECV and thus, enable broader use of hepatic ECV in routine clinical practice.
Identifiants
pubmed: 34109447
doi: 10.1007/s00261-021-03140-6
pii: 10.1007/s00261-021-03140-6
pmc: PMC8435519
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4637-4646Informations de copyright
© 2021. The Author(s).
Références
Abdom Radiol (NY). 2021 Jun;46(6):2458-2466
pubmed: 33078245
Am J Gastroenterol. 2001 Mar;96(3):919-20
pubmed: 11280582
Abdom Radiol (NY). 2020 Sep;45(9):2680-2687
pubmed: 32274552
Top Magn Reson Imaging. 2018 Oct;27(5):319-333
pubmed: 30289828
J Cardiovasc Magn Reson. 2018 Mar 15;20(1):19
pubmed: 29544519
Clin Gastroenterol Hepatol. 2015 Mar;13(3):440-451.e6
pubmed: 25305349
Circulation. 2012 Sep 4;126(10):1206-16
pubmed: 22851543
Radiology. 2017 Aug;284(2):401-412
pubmed: 28045604
Magn Reson Med. 2001 Apr;45(4):533-42
pubmed: 11283978
Magn Reson Imaging. 2021 Apr;77:7-13
pubmed: 33309923
Eur J Radiol. 2021 Apr;137:109604
pubmed: 33618210
Eur Heart J. 2012 May;33(10):1268-78
pubmed: 22279111
Gut. 2018 Mar;67(3):593-594
pubmed: 28754777
J Cardiovasc Magn Reson. 2017 Aug 2;19(1):58
pubmed: 28768519
Magn Reson Med. 2004 Sep;52(3):679-82
pubmed: 15334591
Magn Reson Imaging. 1986;4(4):285-91
pubmed: 3118123
Clin Radiol. 1987 Sep;38(5):495-502
pubmed: 3311563
Magn Reson Med. 2016 Jul;76(1):270-81
pubmed: 26285144
Radiology. 2018 Sep;288(3):748-754
pubmed: 29944086
J Hepatol. 2019 Jan;70(1):151-171
pubmed: 30266282
Magn Reson Imaging. 1982;1(4):209-26
pubmed: 6927208
Abdom Imaging. 2015 Apr;40(4):818-34
pubmed: 24711064
BMC Med Imaging. 2021 Apr 7;21(1):65
pubmed: 33827475
Radiology. 2016 Mar;278(3):658-76
pubmed: 26885733
J Viral Hepat. 2014 Dec;21(12):930-7
pubmed: 24472062
Magn Reson Imaging. 1990;8(5):599-604
pubmed: 2082130
Magn Reson Med. 1990 Jul;15(1):58-69
pubmed: 2374500
JACC Cardiovasc Imaging. 2016 Jan;9(1):54-63
pubmed: 26762875
Magn Reson Med Sci. 2012;11(4):265-71
pubmed: 23269013
J Cardiovasc Magn Reson. 2013 Jun 21;15:56
pubmed: 23800276
J Cardiovasc Magn Reson. 2013 Jan 20;15:13
pubmed: 23331520
Clin Gastroenterol Hepatol. 2020 Nov;18(12):2650-2666
pubmed: 31401364
Magn Reson Med. 2004 Jul;52(1):141-6
pubmed: 15236377
AJR Am J Roentgenol. 2019 Mar 5;:1-6
pubmed: 30835515
Hepatology. 2006 Jun;43(6):1317-25
pubmed: 16729309
Radiology. 2014 Sep;272(3):683-9
pubmed: 24702727