The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI).
Autism
Folic acid
Pregnancy cohort
Prenatal vitamins
Journal
Journal of autism and developmental disorders
ISSN: 1573-3432
Titre abrégé: J Autism Dev Disord
Pays: United States
ID NLM: 7904301
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
accepted:
24
05
2021
pubmed:
11
6
2021
medline:
20
5
2022
entrez:
10
6
2021
Statut:
ppublish
Résumé
We examined maternal prenatal vitamin use or supplemental folic acid intake during month one of pregnancy for association with autism spectrum disorder (ASD) in the Early Autism Risk Longitudinal Investigation, an enriched-risk pregnancy cohort. Total folic acid intake was calculated from monthly prenatal vitamins, multivitamins, and other supplement reports. Clinical assessments through age 3 years classified children as ASD (n = 38) or non-ASD (n = 153). In pregnancy month one, prenatal vitamin use (59.7%) was not significantly associated with odds of ASD (OR = 0.70, 95%CI 0.32, 1.53). Sample size was limited and residual confounding was possible. Given the estimated effect sizes in this and previous work, prenatal vitamin intake during early pregnancy could be a clinically useful preventative measure for ASD.
Identifiants
pubmed: 34110557
doi: 10.1007/s10803-021-05110-9
pii: 10.1007/s10803-021-05110-9
doi:
Substances chimiques
Vitamins
0
Folic Acid
935E97BOY8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2801-2811Subventions
Organisme : NIEHS NIH HHS
ID : R01ES016443
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007863
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025574
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30ES017885
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025531
Pays : United States
Organisme : Autism Speaks
ID : 003953
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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