Time-domain NMR analysis for the determination of water content in pharmaceutical ingredients and wet granules.

Drug Compounding Excipients Powders Tablets Water
Disintegrant Partial least squares regression T(2) relaxation Time-domain NMR Water content quantification Wet granulation

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
15 Jul 2021
Historique:
received: 11 02 2021
revised: 06 05 2021
accepted: 01 06 2021
pubmed: 11 6 2021
medline: 28 7 2021
entrez: 10 6 2021
Statut: ppublish

Résumé

The application of time-domain NMR (TD-NMR) analysis to quantify water content in pharmaceutical ingredients is demonstrated. The initial phase of the study employed a range of disintegrants with defined amounts of added water (0-30% of the total weight) as samples; the disintegrants included croscarmellose sodium, corn starch, low-substituted hydroxypropyl cellulose, and crospovidone. After acquisition of the T

Identifiants

DOI: 10.1016/j.ijpharm.2021.120770 PMID: 34111545
pubmed: 34111545
pii: S0378-5173(21)00575-5
doi: 10.1016/j.ijpharm.2021.120770
pii:
doi:

Substances chimiques

Excipients 0
Powders 0
Tablets 0
Water 059QF0KO0R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120770

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Kosuke Ohgi (K)

Laboratory of Pharmaceutical Technology, School of Pharmacy and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.

Yoshihiro Hayashi (Y)

Formulation Development Department, Development & Planning Division, Nichi-Iko Pharmaceutical Co., Ltd., 205-1, Shimoumezawa Namerikawa-shi, Toyama 936-0857, Japan.

Takahiro Tsuji (T)

Formulation Development Department, Development & Planning Division, Nichi-Iko Pharmaceutical Co., Ltd., 205-1, Shimoumezawa Namerikawa-shi, Toyama 936-0857, Japan.

Terushi Ito (T)

Formulation Development Department, Development & Planning Division, Nichi-Iko Pharmaceutical Co., Ltd., 205-1, Shimoumezawa Namerikawa-shi, Toyama 936-0857, Japan.

Kok Hoong Leong (KH)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Shui Usuda (S)

Laboratory of Pharmaceutical Technology, School of Pharmacy and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.

Shungo Kumada (S)

Formulation Development Department, Development & Planning Division, Nichi-Iko Pharmaceutical Co., Ltd., 205-1, Shimoumezawa Namerikawa-shi, Toyama 936-0857, Japan.

Kotaro Okada (K)

Laboratory of Pharmaceutical Technology, School of Pharmacy and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.

Yoshinori Onuki (Y)

Laboratory of Pharmaceutical Technology, School of Pharmacy and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan. Electronic address: onuki@pha.u-toyama.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Time-domain NMR analysis for the determination...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Excipients › Time-domain NMR analysis for the determination...
questionsmedicales.fr › Préparations pharmaceutiques › Poudres › Time-domain NMR analysis for the determination...
questionsmedicales.fr › Préparations pharmaceutiques › Comprimés › Time-domain NMR analysis for the determination...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Time-domain NMR analysis for the determination...