Association between frailty and ischemic heart disease: a systematic review and meta-analysis.
Frailty
Ischemic heart disease
Metanalysis
Systematic review
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
10 06 2021
10 06 2021
Historique:
received:
09
12
2020
accepted:
26
05
2021
entrez:
11
6
2021
pubmed:
12
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic heart disease (IHD). We performed a systematic review of literature and a meta-analysis to assess the association between frailty and IHD. We selected all the studies that provided information on the association between frailty and IHD, regardless of the study setting, study design, or definition of IHD and frailty. PubMed, Web of Science and Embase were searched for relevant papers. Studies that adopted the Fried definition for frailty were included in the meta-analyses. For each measure of interest (proportions and estimates of associations), a meta-analysis was performed if at least three studies used the same definition of frailty. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Thirty-seven studies were included. Of these, 22 adopted the Fried criteria to define frailty and provided estimates of prevalence and therefore they were included in meta-analyses. The pooled prevalence of IHD in frail individuals was 17% (95% Confidence Interval [95%CI] 11-23%) and the pooled prevalence of frailty in individuals with IHD was 19% (95% CI 15-24%). The prevalence of frailty among IHD patients ranged from 4 to 61%. Insufficient data were found to assess longitudinal association between frailty and IHD. Frailty is quite common in older persons with IHD. The identification of frailty among older adults with IHD should be considered relevant to provide individualized strategies of cardiovascular prevention and care. Further research should specifically explore the association between frailty and IHD and investigate the potential common biological ground.
Sections du résumé
BACKGROUND
Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic heart disease (IHD). We performed a systematic review of literature and a meta-analysis to assess the association between frailty and IHD.
METHODS
We selected all the studies that provided information on the association between frailty and IHD, regardless of the study setting, study design, or definition of IHD and frailty. PubMed, Web of Science and Embase were searched for relevant papers. Studies that adopted the Fried definition for frailty were included in the meta-analyses. For each measure of interest (proportions and estimates of associations), a meta-analysis was performed if at least three studies used the same definition of frailty. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting.
RESULTS
Thirty-seven studies were included. Of these, 22 adopted the Fried criteria to define frailty and provided estimates of prevalence and therefore they were included in meta-analyses. The pooled prevalence of IHD in frail individuals was 17% (95% Confidence Interval [95%CI] 11-23%) and the pooled prevalence of frailty in individuals with IHD was 19% (95% CI 15-24%). The prevalence of frailty among IHD patients ranged from 4 to 61%. Insufficient data were found to assess longitudinal association between frailty and IHD.
CONCLUSIONS
Frailty is quite common in older persons with IHD. The identification of frailty among older adults with IHD should be considered relevant to provide individualized strategies of cardiovascular prevention and care. Further research should specifically explore the association between frailty and IHD and investigate the potential common biological ground.
Identifiants
pubmed: 34112104
doi: 10.1186/s12877-021-02304-9
pii: 10.1186/s12877-021-02304-9
pmc: PMC8193864
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
357Subventions
Organisme : European Commission
ID : 3rd Health Programme, under the Grant Agreement n° 724099
Références
J Am Geriatr Soc. 2012 Aug;60(8):1487-92
pubmed: 22881367
Biochemistry (Mosc). 2016 Nov;81(11):1358-1370
pubmed: 27914461
JACC Cardiovasc Interv. 2012 Sep;5(9):974-81
pubmed: 22995885
J Am Geriatr Soc. 2017 Jan;65(1):179-184
pubmed: 27861714
Clin Cardiol. 2014 Dec;37(12):725-32
pubmed: 25516357
Int J Cardiol. 2017 Jun 1;236:283-289
pubmed: 28215466
Arch Intern Med. 2002 Nov 11;162(20):2333-41
pubmed: 12418947
Circulation. 2019 Mar 5;139(10):e56-e528
pubmed: 30700139
Ageing Res Rev. 2015 May;21:78-94
pubmed: 25846451
Eur Geriatr Med. 2019 Feb;10(1):9-36
pubmed: 32720270
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
J Geriatr Cardiol. 2015 Nov;12(6):662-7
pubmed: 26788044
J Am Geriatr Soc. 2018 Mar;66(3):496-502
pubmed: 29368330
Circulation. 2016 May 24;133(21):2103-22
pubmed: 27067230
Clin Chem. 2019 Jan;65(1):80-86
pubmed: 30504259
Ageing Res Rev. 2017 May;35:63-73
pubmed: 28143778
J Am Med Dir Assoc. 2015 Nov 1;16(11):940-5
pubmed: 26255709
Lancet. 2013 Mar 2;381(9868):752-62
pubmed: 23395245
Am J Geriatr Cardiol. 2008 Mar-Apr;17(2):101-7
pubmed: 18326951
Can J Cardiol. 2013 Dec;29(12):1610-5
pubmed: 24183299
Heart. 2013 May;99(10):737-42
pubmed: 23503403
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Ageing Res Rev. 2019 Jul;52:1-6
pubmed: 30930229
Eur Heart J Acute Cardiovasc Care. 2018 Mar;7(2):176-193
pubmed: 29451402
CMAJ. 2005 Aug 30;173(5):489-95
pubmed: 16129869
PLoS One. 2014 Mar 13;9(3):e90475
pubmed: 24625791
Eur J Intern Med. 2016 Jun;31:3-10
pubmed: 27039014
BMC Geriatr. 2019 Aug 15;19(1):222
pubmed: 31416442
J Aging Res. 2014;2014:198603
pubmed: 25405033
J Am Coll Cardiol. 2015 Mar 17;65(10):976-83
pubmed: 25766943
BMJ Open. 2018 Dec 28;8(12):e024406
pubmed: 30593554
Clin Nutr. 2010 Apr;29(2):154-9
pubmed: 20060626
J Am Heart Assoc. 2018 Dec 4;7(23):e008251
pubmed: 30571603
J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e1-1097.e10
pubmed: 29079033
J Am Med Dir Assoc. 2013 Nov;14(11):851.e1-6
pubmed: 24103860
J Am Coll Cardiol. 2014 Mar 4;63(8):747-62
pubmed: 24291279
J Gerontol A Biol Sci Med Sci. 2020 May 22;75(6):1113-1119
pubmed: 31075167
Aging Cell. 2017 Jun;16(3):444-450
pubmed: 28266167
J Am Heart Assoc. 2018 Sep 18;7(18):e009859
pubmed: 30371219
Eur J Epidemiol. 2014 Jun;29(6):419-27
pubmed: 24935872
Lancet. 2019 Oct 12;394(10206):1365-1375
pubmed: 31609228
Aging Dis. 2018 Jun 1;9(3):489-497
pubmed: 29896436
J Clin Epidemiol. 2009 Oct;62(10):e1-34
pubmed: 19631507
Eur J Intern Med. 2018 Oct;56:33-38
pubmed: 29936074
J Am Med Dir Assoc. 2014 Apr;15(4):281-6
pubmed: 24534517
Wien Klin Wochenschr. 2020 Jun;132(11-12):301-309
pubmed: 32342196