Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain.
Adult Stem Cells
/ physiology
Animals
Astrocytes
/ cytology
Axons
/ physiology
Cell Differentiation
Cell Division
Cerebral Ventricles
/ cytology
Ependyma
/ cytology
Female
Gene Expression Profiling
Homeostasis
Lateral Ventricles
/ cytology
Male
Mice
Neural Stem Cells
/ physiology
Neurogenesis
Neuroglia
/ physiology
Olfactory Bulb
/ cytology
Oligodendroglia
/ cytology
Receptor, Platelet-Derived Growth Factor beta
/ genetics
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
received:
03
02
2021
accepted:
16
04
2021
entrez:
11
6
2021
pubmed:
12
6
2021
medline:
22
6
2021
Statut:
ppublish
Résumé
Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity.
Identifiants
pubmed: 34112692
pii: 372/6547/1205
doi: 10.1126/science.abg8467
doi:
Substances chimiques
Receptor, Platelet-Derived Growth Factor beta
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1205-1209Subventions
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS074039
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS089252
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.