Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children's hospitals neonatal intensive care units (NICUs).
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
25
01
2021
accepted:
18
05
2021
revised:
06
05
2021
pubmed:
12
6
2021
medline:
21
10
2021
entrez:
11
6
2021
Statut:
ppublish
Résumé
To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs. Retrospective cohort of infants in the Children's Hospitals National Consortium (CHNC) from 2010 to 2016 categorized into three groups by treatment received: surgical, intensive medical, or non-intensive. Among 467 infants admitted, 62% received intensive medical treatment; 27% received surgical treatment. The most common surgery was a gastrostomy tube. Survival in infants who received surgeries was 51%; intensive medical treatment was 30%, and non-intensive treatment was 72%. Infants receiving surgeries spent more time in the NICU and were more likely to receive oxygen and feeding support at discharge. Infants with T13 or T18 at CHNC NICUs represent a select group for whom parents may have desired more intensive treatment. Survival to NICU discharge was possible, and surviving infants had a longer hospital stay and needed more discharge supports.
Identifiants
pubmed: 34112961
doi: 10.1038/s41372-021-01111-9
pii: 10.1038/s41372-021-01111-9
pmc: PMC8191443
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1745-1754Investigateurs
Anthony Piazza
(A)
Gregory Sysyn
(G)
Carl Coghill
(C)
Ajay Talati
(A)
Anne Hansen
(A)
Tanzeema Houssain
(T)
Karna Murthy
(K)
Gustave Falciglia
(G)
Beth Haberman
(B)
Kristina Reber
(K)
Rashmin Savani
(R)
Theresa Grover
(T)
Girija Natarajan
(G)
Annie Chi
(A)
Yvette Johnson
(Y)
Gautham Suresh
(G)
William Engle
(W)
Eugenia Pallotto
(E)
Robert Lyle
(R)
Becky Rogers
(B)
Rachel Chapman
(R)
Jamie Limjoco
(J)
Priscilla Joe
(P)
Jacquelyn Evans
(J)
Michael Padula
(M)
David Munson
(D)
Suzanne Touch
(S)
Beverly Brozanski
(B)
Rakesh Rao
(R)
Amit Mathur
(A)
Victor McKay
(V)
Mark Speziale
(M)
Laurel Moyer
(L)
Billie Short
(B)
Kevin Sullivan
(K)
Con Yee Ling
(CY)
Michael Uhing
(M)
Lynne Willett
(L)
Nicole Birge
(N)
Rajan Wadhawan
(R)
Elizabeth Jacobsen-Misbe
(E)
Robert DiGeronimo
(R)
Kyong-Soon Lee
(KS)
Michel Mikhael
(M)
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.
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