IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report.
IgA deficiency
membranoproliferative glomerulonephritis
nephrotic syndrome
Journal
International medical case reports journal
ISSN: 1179-142X
Titre abrégé: Int Med Case Rep J
Pays: New Zealand
ID NLM: 101566269
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
02
2021
accepted:
04
05
2021
entrez:
11
6
2021
pubmed:
12
6
2021
medline:
12
6
2021
Statut:
epublish
Résumé
Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined. We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found. Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.
Sections du résumé
BACKGROUND
BACKGROUND
Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined.
CASE PRESENTATION
METHODS
We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found.
CONCLUSION
CONCLUSIONS
Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.
Identifiants
pubmed: 34113180
doi: 10.2147/IMCRJ.S303038
pii: 303038
pmc: PMC8185457
doi:
Types de publication
Case Reports
Langues
eng
Pagination
377-380Informations de copyright
© 2021 Pezzutto et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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