Development of a Coronavirus Disease 2019 (COVID-19) Application Ontology for the Accrual to Clinical Trials (ACT) network.
COVID-19
clinical data network
electronic health records
ontology
Journal
JAMIA open
ISSN: 2574-2531
Titre abrégé: JAMIA Open
Pays: United States
ID NLM: 101730643
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
01
02
2021
accepted:
15
04
2021
entrez:
11
6
2021
pubmed:
12
6
2021
medline:
12
6
2021
Statut:
epublish
Résumé
Clinical data networks that leverage large volumes of data in electronic health records (EHRs) are significant resources for research on coronavirus disease 2019 (COVID-19). Data harmonization is a key challenge in seamless use of multisite EHRs for COVID-19 research. We developed a COVID-19 application ontology in the national Accrual to Clinical Trials (ACT) network that enables harmonization of data elements that are critical to COVID-19 research. The ontology contains over 50 000 concepts in the domains of diagnosis, procedures, medications, and laboratory tests. In particular, it has computational phenotypes to characterize the course of illness and outcomes, derived terms, and harmonized value sets for severe acute respiratory syndrome coronavirus 2 laboratory tests. The ontology was deployed and validated on the ACT COVID-19 network that consists of 9 academic health centers with data on 14.5M patients. This ontology, which is freely available to the entire research community on GitHub at https://github.com/shyamvis/ACT-COVID-Ontology, will be useful for harmonizing EHRs for COVID-19 research beyond the ACT network.
Identifiants
pubmed: 34113801
doi: 10.1093/jamiaopen/ooab036
pii: ooab036
pmc: PMC8083220
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ooab036Subventions
Organisme : NLM NIH HHS
ID : R01 LM013345
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Medical Informatics Association.
Références
J Am Med Inform Assoc. 2021 Feb 10;:
pubmed: 33566082
J Am Med Inform Assoc. 2021 Mar 1;28(3):427-443
pubmed: 32805036
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D267-70
pubmed: 14681409
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):578-82
pubmed: 24821743
J Am Med Inform Assoc. 2009 Sep-Oct;16(5):624-30
pubmed: 19567788
NPJ Digit Med. 2020 Aug 19;3:109
pubmed: 32864472
J Am Med Inform Assoc. 2010 Mar-Apr;17(2):124-30
pubmed: 20190053
Acta Biomed. 2020 Mar 19;91(1):157-160
pubmed: 32191675
N Engl J Med. 2019 Aug 15;381(7):668-676
pubmed: 31412182
JAMIA Open. 2018 Oct;1(2):147-152
pubmed: 30474072
J Am Med Inform Assoc. 2012 Mar-Apr;19(2):181-5
pubmed: 22081225
Stud Health Technol Inform. 2015;216:574-8
pubmed: 26262116