The elegant complexity of mammalian ecto-5'-nucleotidase (CD73).
adenosine
cancer
digestive system
inflammation
purinergic system
zonation
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
26
02
2021
revised:
10
05
2021
accepted:
14
05
2021
pubmed:
13
6
2021
medline:
15
12
2021
entrez:
12
6
2021
Statut:
ppublish
Résumé
Purinergic signaling is a fundamental mechanism used by all cells to control their internal activities and interact with the environment. A key component of the purinergic system, the enzyme ecto-5'-nucleotidase (CD73) catalyzes the last step in the extracellular metabolism of ATP to form adenosine. Efforts to harness the therapeutic potential of endogenous adenosine in cancer have culminated in the ongoing clinical development of multiple CD73-targeting antibodies and small-molecule inhibitors. However, recent studies are painting an increasingly complex picture of CD73 mRNA and protein regulation and function in cellular homeostasis, physiological adaptation, and disease development. This review discusses the latest conceptual and methodological advances that are helping to unravel the complexity of this important enzyme that was identified nearly 90 years ago.
Identifiants
pubmed: 34116887
pii: S0962-8924(21)00100-8
doi: 10.1016/j.tcb.2021.05.008
pmc: PMC8448938
mid: NIHMS1713066
pii:
doi:
Substances chimiques
RNA, Messenger
0
Adenosine Monophosphate
415SHH325A
5'-Nucleotidase
EC 3.1.3.5
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-842Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110355
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA071341
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no conflicts of interest.
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