Mechanisms for the Sour Taste.
Acid
Circuit
Otopetrin
Prodynorphin
Proenkephalin
Somatosensory
Sour
Taste
Taste receptor
Journal
Handbook of experimental pharmacology
ISSN: 0171-2004
Titre abrégé: Handb Exp Pharmacol
Pays: Germany
ID NLM: 7902231
Informations de publication
Date de publication:
2022
2022
Historique:
pubmed:
13
6
2021
medline:
16
6
2022
entrez:
12
6
2021
Statut:
ppublish
Résumé
Sour, the taste of acids, provides important sensory information to prevent the ingestion of unripe, spoiled, or fermented foods. In mammals, acids elicit disgust and pain by simultaneously activating taste and somatosensory neurons innervating the oral cavity. Early researchers detected electrical activity in taste nerves upon presenting acids to the tongue, establishing this as the bona fide sour taste. Recent studies have made significant contributions to our understanding of the mechanisms underlying acid sensing in the taste receptor cells at the periphery and the neural circuitry that convey this information to the brain. In this chapter, we discuss the characterization of sour taste receptor cells, the twists and turns eventually leading to the identification of Otopetrin1 (OTOP1) as the sour taste receptor, the pathway of sour taste signaling from the tongue to the brainstem, and other roles sour taste receptor cells play in the taste bud.
Identifiants
pubmed: 34117536
doi: 10.1007/164_2021_476
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
229-245Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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