Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging.
Aging
Cadmium
Comparative biogerontology
Longevity
Mammals
Metallothionein
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
30
12
2020
accepted:
24
05
2021
pubmed:
13
6
2021
medline:
29
10
2021
entrez:
12
6
2021
Statut:
ppublish
Résumé
Cadmium (Cd) accumulates with aging and is elevated in long-lived species. Metallothioneins (MTs), small cysteine-rich proteins involved in metal homeostasis and Cd detoxification, are known to be related to longevity. However, the relationship between Cd accumulation, the role of MTs, and aging is currently unclear. Specifically, we do not know if long-lived species evolved an efficient metal stress response by upregulating their MT levels to reduce the toxic effects of environmental pollutants, such as Cd, that accumulate over their longer life span. It is also unknown if the number of MT genes, their expression, or both protect the organisms from potentially damaging effects during aging. To address these questions, we reanalyzed several cross-species studies and obtained data on MT expression and Cd accumulation in long-lived mouse models. We confirmed a relationship between species maximum life span in captive mammals and their Cd content in liver and kidney. We found that although the number of MT genes does not affect longevity, gene expression and protein amount of specific MT paralogs are strongly related to life span in mammals. MT expression rather than gene number may influence the high Cd levels and longevity of some species. In support of this, we found that overexpression of MT-1 accelerated Cd accumulation in mice and that tissue Cd was higher in long-lived mouse strains with high MT expression. We conclude that long-lived species have evolved a more efficient stress response by upregulating the expression of MT genes in presence of Cd, which contributes to elevated tissue Cd levels.
Identifiants
pubmed: 34117600
doi: 10.1007/s11357-021-00393-3
pii: 10.1007/s11357-021-00393-3
pmc: PMC8492847
doi:
Substances chimiques
Cadmium
00BH33GNGH
Metallothionein
9038-94-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1975-1993Informations de copyright
© 2021. American Aging Association.
Références
Ageing Res Rev. 2011 Jan;10(1):132-45
pubmed: 20933613
Nature. 1996 Nov 7;384(6604):33
pubmed: 8900272
Toxicol Appl Pharmacol. 1986 Mar 15;82(3):417-25
pubmed: 3952727
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5
pubmed: 23193258
Environ Health Perspect. 2014 May;122(5):431-8
pubmed: 24569905
Exp Gerontol. 2013 Jan;48(1):94-8
pubmed: 22525591
Nucleic Acids Res. 2013 Jan;41(Database issue):D1027-33
pubmed: 23193293
Physiol Rev. 1985 Apr;65(2):238-309
pubmed: 3885271
Chemosphere. 2020 Apr;245:125533
pubmed: 31855751
Free Radic Biol Med. 2019 Apr;134:311-326
pubmed: 30625394
Exp Gerontol. 2010 May;45(5):366-74
pubmed: 20197085
Nat Protoc. 2009;4(8):1184-91
pubmed: 19617889
Free Radic Res. 2010 Jun;44(6):605-13
pubmed: 20380594
Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E942-50
pubmed: 23941873
Exp Gerontol. 2016 Jan;73:28-30
pubmed: 26615880
Yakugaku Zasshi. 2007 Apr;127(4):665-73
pubmed: 17409696
Mol Ecol. 2013 Feb;22(3):620-34
pubmed: 22998089
Environ Res. 1989 Jun;49(1):104-14
pubmed: 2721471
Nature. 2009 Jul 16;460(7253):392-5
pubmed: 19587680
BMC Genomics. 2018 Jan 8;19(1):32
pubmed: 29310597
Toxicol Lett. 1994 Oct;74(1):23-33
pubmed: 8085268
Int J Epidemiol. 2016 Jun;45(3):782-91
pubmed: 25997435
Aging Cell. 2007 Feb;6(1):1-13
pubmed: 17156084
Aging Cell. 2005 Aug;4(4):167-75
pubmed: 16026331
Aging Cell. 2015 Jun;14(3):352-65
pubmed: 25677554
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nature. 2007 Mar 29;446(7135):507-12
pubmed: 17392779
Chemosphere. 2018 Nov;211:855-860
pubmed: 30103140
Cell Rep. 2015 Nov 17;13(7):1319-1326
pubmed: 26549444
Biochim Biophys Acta. 2005 Mar 14;1747(2):205-11
pubmed: 15698955
Toxicol Appl Pharmacol. 1995 Aug;133(2):305-12
pubmed: 7645027
NPJ Aging Mech Dis. 2017 Sep 29;3:14
pubmed: 28970944
Cancer Res. 1999 Apr 1;59(7):1642-8
pubmed: 10197641
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1989;93(2):327-32
pubmed: 2572387
PLoS One. 2011;6(11):e26729
pubmed: 22073188
J Pharm Biomed Anal. 2016 Jan 5;117:464-73
pubmed: 26454339
Ecol Appl. 2015 Apr;25(3):596-602
pubmed: 26214907
Biol Trace Elem Res. 2002 Summer;87(1-3):95-111
pubmed: 12117236
PLoS Genet. 2018 Mar 23;14(3):e1007272
pubmed: 29570707
PLoS One. 2014 Jan 07;9(1):e83988
pubmed: 24409289
J Expo Sci Environ Epidemiol. 2007 Jan;17(1):39-46
pubmed: 16955091
Hepatology. 2015 Feb;61(2):613-26
pubmed: 25179284
Fundam Appl Toxicol. 1996 Feb;29(2):294-300
pubmed: 8742328
Nature. 2012 Nov 15;491(7424):444-8
pubmed: 23123857
PLoS One. 2017 Jun 20;12(6):e0177432
pubmed: 28632756
J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):149-60
pubmed: 17339640
Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515
pubmed: 30395287
Toxicol Appl Pharmacol. 2009 Aug 1;238(3):201-8
pubmed: 19409405
Exp Eye Res. 2008 Jan;86(1):41-51
pubmed: 17967453
Biometals. 2010 Oct;23(5):897-926
pubmed: 20549307
Biol Trace Elem Res. 2004 Feb;97(2):135-48
pubmed: 14985624
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8321-6
pubmed: 18559853
Biometals. 2016 Jun;29(3):423-32
pubmed: 27067444
J Exp Biol. 2011 Jun 1;214(Pt 11):1902-10
pubmed: 21562178
Aging (Albany NY). 2014 Nov;6(11):975-91
pubmed: 25554795
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Biochem Pharmacol. 2000 Jan 1;59(1):95-104
pubmed: 10605938
Biogerontology. 2006 Oct-Dec;7(5-6):357-65
pubmed: 16955215
Ecol Appl. 2018 Apr;28(3):605-611
pubmed: 29676862
Nucleic Acids Res. 2015 Jan;43(Database issue):D737-42
pubmed: 25392405
Database (Oxford). 2018 Jan 1;2018:
pubmed: 30576484
FASEB J. 2006 May;20(7):1024-6
pubmed: 16585059
Chemosphere. 2015 Mar;122:14-22
pubmed: 25441931
Free Radic Biol Med. 1993 Mar;14(3):325-37
pubmed: 8458590
Biol Trace Elem Res. 2008 Mar;121(3):205-14
pubmed: 17957345
Am J Epidemiol. 2015 Jan 15;181(2):127-36
pubmed: 25504027
Exp Gerontol. 2015 Jun;66:21-4
pubmed: 25871729
PLoS One. 2012;7(3):e33204
pubmed: 22413003
Diabetes. 2017 Feb;66(2):529-542
pubmed: 27903744
Mol Med. 2007 Jul-Aug;13(7-8):371-5
pubmed: 17622324
Rejuvenation Res. 2012 Apr;15(2):140-3
pubmed: 22533418
Mol Ecol Resour. 2017 Jul;17(4):656-669
pubmed: 27762098
J Mol Evol. 2014 Apr;78(3-4):217-33
pubmed: 24557429
Age (Dordr). 2013 Dec;35(6):2303-13
pubmed: 23640425
J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753
pubmed: 29045571
Sci Total Environ. 1986 Dec 1;57:57-65
pubmed: 3810147
J Circadian Rhythms. 2012 Jul 24;10(1):5
pubmed: 22827964
J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):10-9
pubmed: 24522391
Adv Anat Embryol Cell Biol. 2016;218:1-117
pubmed: 26847563