COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men.
Adult
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
Antibody Formation
/ immunology
COVID-19
/ immunology
COVID-19 Vaccines
/ immunology
Female
Humans
Immunoglobulin G
/ immunology
Immunologic Tests
/ methods
Male
Middle Aged
Neutralization Tests
/ methods
SARS-CoV-2
/ immunology
Spike Glycoprotein, Coronavirus
/ immunology
Vaccination
/ methods
Vaccines, Synthetic
/ immunology
mRNA Vaccines
COVID-19
ELISA
IgG
SARS-CoV-2
dried blood spots
neutralizing
receptor binding domain
serological testing
vaccine
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
16
04
2021
accepted:
09
06
2021
pubmed:
13
6
2021
medline:
29
9
2021
entrez:
12
6
2021
Statut:
ppublish
Résumé
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
Identifiants
pubmed: 34117873
pii: 6297423
doi: 10.1093/infdis/jiab314
pmc: PMC8536925
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Immunoglobulin G
0
Spike Glycoprotein, Coronavirus
0
Vaccines, Synthetic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-797Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : Northwestern University Office of Research
Organisme : National Science Foundation
ID : 2035114
Organisme : NIH HHS
ID : 3UL1TR001422-06S4
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
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