Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type.
BAY11-7082
EAN
GBS
NF-κB
macrophages
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
10
06
2021
received:
27
04
2021
accepted:
10
06
2021
pubmed:
13
6
2021
medline:
24
12
2021
entrez:
12
6
2021
Statut:
ppublish
Résumé
Guillain-Barré syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of the peripheral nervous system (PNS). Macrophages play a central role in its animal model, experimental autoimmune neuritis (EAN), which has been well accepted. Additionally, nuclear factor (NF)-κB inhibitors have been used to treat cancers and have shown beneficial effects. Here, we investigated the therapeutic effect of M2 macrophage and the NF-κB pathway's correlation with macrophage activation in EAN in C57BL/6 mice. We demonstrate that M2 macrophage transfusion could alleviate the clinical symptoms of EAN by reducing the proportion of M1 macrophage in the peak period, inhibiting the phosphorylation of NF-κB p65. The NF-κB inhibitor (BAY-11-7082) could alleviate the clinical symptoms of EAN and shorten the duration of symptoms by reducing the proportion of M1 macrophages and the expression of proinflammatory cytokines. Consequently, BAY-11-7082 exhibits strong potential as a therapeutic strategy for ameliorating EAN by influencing the balance of M1/M2 macrophages and inflammatory cytokines.
Identifiants
pubmed: 34118070
doi: 10.1111/cei.13637
pmc: PMC8446411
doi:
Substances chimiques
3-(4-methylphenylsulfonyl)-2-propenenitrile
0
Nitriles
0
Rela protein, mouse
0
Sulfones
0
Transcription Factor RelA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-117Subventions
Organisme : Swedish Research Council
ID : 2015-03005
Organisme : National Natural Science Foundation of China
ID : 81471216
Organisme : National Natural Science Foundation of China
ID : 81671186
Organisme : National Natural Science Foundation of China
ID : 81671177
Informations de copyright
© 2021 British Society for Immunology.
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