7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19.
7-Ketocholesterol
Adjuvant therapies
COVID-19
Oxysterols
SARS-CoV-2
Viral diseases
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
29
04
2021
revised:
04
06
2021
accepted:
07
06
2021
pubmed:
13
6
2021
medline:
10
9
2021
entrez:
12
6
2021
Statut:
ppublish
Résumé
7-Ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. 7-Ketocholesterol appears to significantly contribute to the development of age-related diseases (cardiovascular diseases, age-related macular degeneration, and Alzheimer's disease), chronic inflammatory bowel diseases and to certain cancers. Recent studies have also shown that 7-ketocholesterol has anti-viral activities, including on SARS-CoV-2, which are, however, lower than those of oxysterols resulting from the oxidation of cholesterol on the side chain. Furthermore, 7-ketocholesterol is increased in the serum of moderately and severely affected COVID-19 patients. In the case of COVID-19, it can be assumed that the antiviral activity of 7-ketocholesterol could be counterbalanced by its toxic effects, including pro-oxidant, pro-inflammatory and pro-coagulant activities that might promote the induction of cell death in alveolar cells. It is therefore suggested that this oxysterol might be involved in the pathophysiology of COVID-19 by contributing to the acute respiratory distress syndrome and promoting a deleterious, even fatal outcome. Thus, 7-ketocholesterol could possibly constitute a lipid biomarker of COVID-19 outcome and counteracting its toxic effects with adjuvant therapies might have beneficial effects in COVID-19 patients.
Identifiants
pubmed: 34118414
pii: S0960-0760(21)00132-1
doi: 10.1016/j.jsbmb.2021.105939
pmc: PMC8188774
pii:
doi:
Substances chimiques
Antiviral Agents
0
Biomarkers
0
Ketocholesterols
0
7-ketocholesterol
O7676FE78M
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105939Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
Exp Eye Res. 2006 Aug;83(2):465-9
pubmed: 16549062
Br J Pharmacol. 2021 Aug;178(16):3115-3123
pubmed: 32579703
Immun Inflamm Dis. 2021 Jun;9(2):331-339
pubmed: 33566457
Redox Biol. 2020 Sep;36:101682
pubmed: 32810737
Biochimie. 2014 Mar;98:102-10
pubmed: 24060512
Chem Phys Lipids. 2017 Oct;207(Pt B):151-170
pubmed: 28408132
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
Cytometry A. 2006 May;69(5):359-73
pubmed: 16604541
Biochem Pharmacol. 2020 Mar;173:113648
pubmed: 31586589
Science. 2020 Sep 25;369(6511):1633-1637
pubmed: 32820063
Curr Alzheimer Res. 2018 Feb 22;15(4):303-312
pubmed: 28474568
Mol Aspects Med. 2009 Jun;30(3):153-70
pubmed: 19248805
J Steroid Biochem Mol Biol. 2017 May;169:123-136
pubmed: 27041118
Microb Cell Fact. 2009 Apr 09;8:21
pubmed: 19358742
Am J Clin Nutr. 2009 Sep;90(3):477-84
pubmed: 19587087
Free Radic Biol Med. 2017 Oct;111:151-155
pubmed: 28428001
Med Arch. 2020 Apr;74(2):134-138
pubmed: 32577056
Antioxid Redox Signal. 2014 Sep 1;21(7):1025-31
pubmed: 24673169
Anal Quant Cytol Histol. 2001 Feb;23(1):47-55
pubmed: 11233743
J Steroid Biochem Mol Biol. 2017 May;169:29-38
pubmed: 26921765
J Am Soc Nephrol. 2007 Apr;18(4):1246-61
pubmed: 17360943
J Steroid Biochem Mol Biol. 2019 Nov;194:105432
pubmed: 31344443
Cell Physiol Biochem. 2019;53(6):933-947
pubmed: 31805226
J Clin Invest. 1993 Mar;91(3):881-8
pubmed: 8450067
Immunity. 2013 Jan 24;38(1):106-18
pubmed: 23273843
Int J Appl Basic Med Res. 2018 Jan-Mar;8(1):1-2
pubmed: 29552526
J Intern Med. 2019 Apr;285(4):367-380
pubmed: 30478861
Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):90-96
pubmed: 29227331
J Ophthalmol. 2011;2011:471947
pubmed: 21577274
Molecules. 2020 Jan 30;25(3):
pubmed: 32019195
J Steroid Biochem Mol Biol. 2017 May;169:96-110
pubmed: 27020660
Elife. 2015 Jun 26;4:e07999
pubmed: 26114596
J Clin Invest. 2002 Oct;110(7):905-11
pubmed: 12370266
Sci Rep. 2014 Dec 15;4:7487
pubmed: 25501851
Oxf Open Immunol. 2020;1(1):iqaa001
pubmed: 33047740
Prostaglandins Other Lipid Mediat. 2020 Apr;147:106381
pubmed: 31698146
J Steroid Biochem Mol Biol. 2019 Oct;193:105426
pubmed: 31301352
J Fr Ophtalmol. 2006 May;29(5):570-8
pubmed: 16885834
Metabolites. 2020 Sep 28;10(10):
pubmed: 32998240
Redox Biol. 2017 Aug;12:182-190
pubmed: 28258022
Cell Biol Toxicol. 2005 Mar;21(2):97-114
pubmed: 16142584
Int J Mol Sci. 2019 Aug 08;20(16):
pubmed: 31398943
PLoS One. 2014 Jul 18;9(7):e100985
pubmed: 25036103
J Clin Invest. 2020 Dec 1;130(12):6204-6213
pubmed: 33085654
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1247-1257
pubmed: 31136841
Ageing Res Rev. 2021 Jul;68:101324
pubmed: 33774195
Crit Rev Food Sci Nutr. 2019;59(19):3179-3198
pubmed: 29993272
Viruses. 2018 Dec 30;11(1):
pubmed: 30598036
Biomed Pharmacother. 2021 May;137:111352
pubmed: 33550050
Nutrients. 2021 Apr 14;13(4):
pubmed: 33919840
Eur J Med Chem. 2013;70:558-67
pubmed: 24211631
Cells. 2021 Jan 21;10(2):
pubmed: 33494237
Antioxidants (Basel). 2020 Jul 17;9(7):
pubmed: 32708926
Viruses. 2020 Jul 06;12(7):
pubmed: 32640529
Rev Med Virol. 2009 Nov;19(6):359-78
pubmed: 19750559
Clin Immunol. 2012 Jan;142(1):44-8
pubmed: 21414846
Eur J Pharmacol. 2021 Jan 5;890:173741
pubmed: 33227287
Trends Analyt Chem. 2019 Nov;120:115280
pubmed: 31839688
Circ Res. 2014 Oct 10;115(9):770-780
pubmed: 25186795
Arterioscler Thromb Vasc Biol. 2004 May;24(5):806-15
pubmed: 14764421
Mol Aspects Med. 2009 Jun;30(3):111-22
pubmed: 19248801
Biochim Biophys Acta. 2015 May;1851(5):605-19
pubmed: 25617738
Redox Biol. 2013 Jan 31;1:125-30
pubmed: 24024145
Nat Rev Microbiol. 2018 Jun;16(6):341-354
pubmed: 29556036
Trends Cardiovasc Med. 2001 Apr-May;11(3-4):131-8
pubmed: 11686002
Free Radic Biol Med. 2010 Jun 1;48(11):1513-24
pubmed: 20219673
Mol Cell Biochem. 2020 Apr;467(1-2):117-125
pubmed: 32108278
Redox Biol. 2016 Dec;10:24-33
pubmed: 27687218
J Biol Chem. 2009 Jun 5;284(23):15826-34
pubmed: 19351882
Biochimie. 2020 Dec;179:247-256
pubmed: 33159981
J Steroid Biochem Mol Biol. 2017 May;169:152-163
pubmed: 27155346
Free Radic Biol Med. 2019 Nov 20;144:124-133
pubmed: 31009661
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4942-55
pubmed: 20554621
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
J Lipid Res. 2011 Jun;52(6):1117-1127
pubmed: 21411718
J Steroid Biochem Mol Biol. 2015 Jul;151:102-7
pubmed: 25218443
Ageing Res Rev. 2014 Nov;18:148-62
pubmed: 25305550
Mol Aspects Med. 2016 Jun;49:23-30
pubmed: 27086126
Scand J Clin Lab Invest. 2021 Feb;81(1):18-23
pubmed: 33403882
Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec;81(5-6):313-24
pubmed: 19857945
Chem Phys Lipids. 2011 Sep;164(6):457-68
pubmed: 21703250
Cell Chem Biol. 2021 Jun 17;28(6):866-875.e5
pubmed: 33636107
J Lipid Res. 2007 Jun;48(6):1343-52
pubmed: 17347498
Front Cell Dev Biol. 2015 May 27;3:35
pubmed: 26075204
Int J Mol Sci. 2021 Mar 19;22(6):
pubmed: 33808940
Biochem Pharmacol. 2013 Jul 1;86(1):130-7
pubmed: 23611834
Arterioscler Thromb. 1994 Jul;14(7):1177-85
pubmed: 8018675
Biochimie. 2018 Oct;153:181-202
pubmed: 30031877
Curr Med Chem. 2021;28(1):110-136
pubmed: 32175830
Exp Eye Res. 2019 Oct;187:107746
pubmed: 31394101
Br J Clin Pharmacol. 2011 Feb;71(2):183-9
pubmed: 21219398
Int J Mol Sci. 2019 Jun 29;20(13):
pubmed: 31261912
Biochem Biophys Res Commun. 2003 Apr 11;303(3):814-24
pubmed: 12670484
Biochem Pharmacol. 2013 Jul 1;86(1):67-79
pubmed: 23473804
Prog Lipid Res. 2016 Oct;64:152-169
pubmed: 27687912
Cell Metab. 2021 Mar 2;33(3):479-498
pubmed: 33529600
Chem Phys Lipids. 2017 Oct;207(Pt B):253-259
pubmed: 28571786
Redox Biol. 2020 Jan;29:101380
pubmed: 31926618
Am J Infect Control. 2020 Sep;48(9):1130-1131
pubmed: 32593810
Int J Oral Sci. 2020 Feb 24;12(1):8
pubmed: 32094336
Curr Opin Infect Dis. 2020 Dec;33(6):540-547
pubmed: 33027185
Adv Exp Med Biol. 2020;1299:31-41
pubmed: 33417205
Redox Biol. 2018 Oct;19:318-330
pubmed: 30212801
Sci Rep. 2015 Mar 16;5:9144
pubmed: 25775051
BMC Res Notes. 2020 Feb 13;13(1):75
pubmed: 32054515
Nat Rev Immunol. 2014 Nov;14(11):731-43
pubmed: 25324126
Exp Eye Res. 1998 May;66(5):645-52
pubmed: 9628811
Redox Biol. 2017 Aug;12:522-527
pubmed: 28359048
Biochimie. 2018 Oct;153:220-231
pubmed: 29894701
Thromb Res. 1996 Sep 15;83(6):449-61
pubmed: 8885139