Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum.
Avian malaria
Haemosporida
Host specificity
Merozoite surface protein 1
Parasite population structure
Plasmodium relictum
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
12 Jun 2021
12 Jun 2021
Historique:
received:
11
03
2021
accepted:
01
06
2021
entrez:
13
6
2021
pubmed:
14
6
2021
medline:
6
10
2021
Statut:
epublish
Résumé
Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.
Sections du résumé
BACKGROUND
BACKGROUND
Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested.
METHODS
METHODS
The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14.
RESULTS
RESULTS
The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe.
CONCLUSION
CONCLUSIONS
The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.
Identifiants
pubmed: 34118950
doi: 10.1186/s12936-021-03799-8
pii: 10.1186/s12936-021-03799-8
pmc: PMC8199812
doi:
Substances chimiques
Merozoite Surface Protein 1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
265Subventions
Organisme : Vetenskapsrådet
ID : 2016-03419
Organisme : COMPETE
ID : POPH/ QREN/FSE
Organisme : Fundação para a Ciência e a Tecnologia
ID : FCOMP-01-0124- FEDER-008941; PTDC/BIA-BEC/103435/2008
Organisme : Fundação para a Ciência e Tecnologia
ID : DL57/2016/CP1440/CT0006
Références
Genomics. 2020 Jul;112(4):2857-2865
pubmed: 32234432
Mol Ecol Resour. 2019 Mar;19(2):400-410
pubmed: 30554480
Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675):
pubmed: 26150666
Genome Res. 2018 Apr;28(4):547-560
pubmed: 29500236
BMC Evol Biol. 2008 Oct 23;8:289
pubmed: 18947398
Nat Rev Microbiol. 2004 Apr;2(4):279-88
pubmed: 15031727
Int J Parasitol. 2015 Sep;45(11):711-9
pubmed: 26056737
Nucleic Acids Res. 2009 Jan;37(Database issue):D539-43
pubmed: 18957442
Malar J. 2018 May 2;17(1):184
pubmed: 29720195
Vet Parasitol. 2010 Oct 11;173(1-2):123-7
pubmed: 20638795
Trends Parasitol. 2012 Feb;28(2):73-82
pubmed: 22100995
Int J Parasitol. 2010 Aug 15;40(10):1155-61
pubmed: 20451527
Parasitology. 2015 Aug;142(9):1215-20
pubmed: 25968571
Bioinformatics. 2003 Aug 12;19(12):1572-4
pubmed: 12912839
Malar J. 2013 Oct 30;12:381
pubmed: 24172200
Bioinformatics. 2013 Nov 1;29(21):2790-1
pubmed: 23975764
Mol Biol Evol. 2005 May;22(5):1185-92
pubmed: 15703244
Trends Parasitol. 2018 Aug;34(8):712-726
pubmed: 29937414
Exp Parasitol. 2015 Jan;148:1-16
pubmed: 25450775
Mol Ecol. 2017 Jun;26(11):2939-2958
pubmed: 28267239
Mol Ecol. 2014 Jul;23(13):3322-9
pubmed: 24689968
Trends Parasitol. 2019 Mar;35(3):254-266
pubmed: 30642725
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Evolution. 2004 Jul;58(7):1617-21
pubmed: 15341164
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13845-50
pubmed: 17693553
Am J Trop Med Hyg. 2007 Jun;76(6):1037-45
pubmed: 17556608
Am Nat. 2020 Jun;195(6):1070-1084
pubmed: 32469658
Proc Biol Sci. 2006 Dec 7;273(1604):2935-44
pubmed: 17015360
BMC Evol Biol. 2012 Feb 17;12:22
pubmed: 22340143
Int J Parasitol. 2018 Oct;48(12):947-954
pubmed: 30107149
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Mol Ecol Resour. 2009 Sep;9(5):1353-8
pubmed: 21564906
J Parasitol. 2004 Aug;90(4):797-802
pubmed: 15357072