Epigenetic "Drivers" of Cancer.

Biomarkers, Tumor / genetics Epigenesis, Genetic Gene Expression Regulation, Neoplastic Gene-Environment Interaction Humans Neoplasms / genetics
cancer cancer epigenetics cancer genetics gene-environment interaction transcriptional rewiring

Journal

Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R

Informations de publication

Date de publication:
23 07 2021
Historique:
received: 21 03 2021
revised: 21 05 2021
accepted: 02 06 2021
pubmed: 14 6 2021
medline: 21 9 2021
entrez: 13 6 2021
Statut: ppublish

Résumé

Genetics is at the basis of cancer initiation and evolution, but emerging evidence indicates that mutations are not sufficient to produce cancer, indicating a role for epigenetic contributions to the different stages of tumorigenesis. While the genetic tracks of cancer have been widely investigated, the epigenetic "drivers" remain a vague definition. Gene-environment interactions can produce gene-regulatory programs that dictate pathogenesis; this implies a reciprocal relationship where environmental factors contribute to genetic mechanisms of tumorigenesis (i.e. mutagenesis) and genetic factors influence the cellular response to extrinsic stress. In this review article, we attempt to summarise the most remarkable findings demonstrating a contribution of epigenetic factors as proper "drivers" of tumorigenesis. We also try to pose attention on the relevance of epigenetic mechanisms as downstream consequences of genes versus environment interaction.

Identifiants

DOI: 10.1016/j.jmb.2021.167094 PMID: 34119490
pubmed: 34119490
pii: S0022-2836(21)00318-1
doi: 10.1016/j.jmb.2021.167094
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

167094

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Alessio Butera (A)

TOR Centre of Excellence, University of Rome Tor Vergata, Italy.

Gerry Melino (G)

TOR Centre of Excellence, University of Rome Tor Vergata, Italy. Electronic address: melino@uniroma2.it.

Ivano Amelio (I)

TOR Centre of Excellence, University of Rome Tor Vergata, Italy; School of Life Sciences, University of Nottingham, UK. Electronic address: ivano.amelio@uniroma2.it.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Epigenetic "Drivers" of Cancer.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic "Drivers" of Cancer.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Epigenetic "Drivers" of Cancer.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › Epigenetic "Drivers" of Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic "Drivers" of Cancer.
questionsmedicales.fr › Tumeurs › Epigenetic "Drivers" of Cancer.