ATP and cancer immunosurveillance.
ADORA2A
CD39
CD73
autophagy
immune checkpoint inhibitors
immunogenic cell death
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
revised:
24
03
2021
received:
25
02
2021
accepted:
05
04
2021
pubmed:
15
6
2021
medline:
18
11
2021
entrez:
14
6
2021
Statut:
ppublish
Résumé
While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic metabolism of all the cellular compartments that form the tumor microenvironment (TME), extracellular ATP operates as a potent signal transducer. The net effects of purinergic signaling on the biology of the TME depend not only on the specific receptors and cell types involved, but also on the activation status of cis- and trans-regulatory circuitries. As an additional layer of complexity, extracellular ATP is rapidly catabolized by ectonucleotidases, culminating in the accumulation of metabolites that mediate distinct biological effects. Here, we discuss the molecular and cellular mechanisms through which ATP and its degradation products influence cancer immunosurveillance, with a focus on therapeutically targetable circuitries.
Identifiants
pubmed: 34121201
doi: 10.15252/embj.2021108130
pmc: PMC8246257
doi:
Substances chimiques
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e108130Informations de copyright
© 2021 The Authors.
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