Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin:
LC-MS
MALDI
Skin
ablative fractional laser
bleomycin
drug delivery
electroporation
imaging
intradermal
laser-assisted drug delivery
mass spectrometry
topical delivery
Journal
Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
14
6
2021
pubmed:
15
6
2021
medline:
18
11
2021
Statut:
ppublish
Résumé
Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellular uptake in the target tissue. Here, we characterize and compare BLM biodistribution patterns, cutaneous pharmacokinetic profiles, and tolerability in an
Identifiants
pubmed: 34121567
doi: 10.1080/10717544.2021.1933649
pmc: PMC8205002
doi:
Substances chimiques
Antibiotics, Antineoplastic
0
Bleomycin
11056-06-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1141-1149Références
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