Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin:


Journal

Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471

Informations de publication

Date de publication:
Dec 2021
Historique:
entrez: 14 6 2021
pubmed: 15 6 2021
medline: 18 11 2021
Statut: ppublish

Résumé

Bleomycin (BLM) is being repositioned in dermato-oncology for intralesional and intra-tumoural use. Although conventionally administered by local needle injections (NIs), ablative fractional lasers (AFLs) can facilitate topical BLM delivery. Adding local electroporation (EP) can augment intracellular uptake in the target tissue. Here, we characterize and compare BLM biodistribution patterns, cutaneous pharmacokinetic profiles, and tolerability in an

Identifiants

pubmed: 34121567
doi: 10.1080/10717544.2021.1933649
pmc: PMC8205002
doi:

Substances chimiques

Antibiotics, Antineoplastic 0
Bleomycin 11056-06-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1141-1149

Références

J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1147-1154
pubmed: 29178483
Biochem Pharmacol. 1988 Dec 15;37(24):4727-33
pubmed: 2462423
Cancer Chemother Pharmacol. 2016 May;77(5):939-47
pubmed: 26992379
Acta Oncol. 2018 Jul;57(7):874-882
pubmed: 29577784
Lasers Surg Med. 2021 Apr;53(4):450-457
pubmed: 32677058
J Environ Pathol Toxicol Oncol. 2007;26(2):105-16
pubmed: 17725536
Biochemistry. 1979 Jan 9;18(1):96-101
pubmed: 84680
Dermatol Ther. 2015 Mar-Apr;28(2):74-8
pubmed: 25471297
Lasers Surg Med. 2021 Jan;53(1):141-147
pubmed: 32515075
J Transl Med. 2017 May 31;15(1):122
pubmed: 28569161
Dermatol Surg. 2008 Oct;34(10):1299-313
pubmed: 18616538
Adv Drug Deliv Rev. 2020 Jan 1;153:169-184
pubmed: 31628965
J Invest Dermatol. 2020 Oct;140(10):2051-2059
pubmed: 32135181
J Am Acad Dermatol. 1997 Oct;37(4):596-9
pubmed: 9344200
J Control Release. 2018 Apr 10;275:242-253
pubmed: 29454062
Adv Drug Deliv Rev. 2020 Jan 1;153:137-146
pubmed: 31778729
Lasers Surg Med. 2021 Jan;53(1):162-170
pubmed: 33161610
Mol Pharm. 2020 Aug 3;17(8):2925-2937
pubmed: 32510228
Lasers Surg Med. 2020 Jan;52(1):33-37
pubmed: 31788834
J Cosmet Laser Ther. 2017 Dec;19(8):451-458
pubmed: 28692322
J Am Acad Dermatol. 2020 Sep;83(3):888-903
pubmed: 32068046
Talanta. 2016 Nov 1;160:164-171
pubmed: 27591601
Br J Cancer. 1998 Jun;77(12):2336-42
pubmed: 9649155
J Am Acad Dermatol. 2019 Oct;81(4):984-988
pubmed: 31202871
Lasers Surg Med. 2021 Jan;53(1):119-128
pubmed: 32960987
Eur J Surg Oncol. 2020 May;46(5):847-854
pubmed: 31862134
Drug Deliv. 2019 Dec;26(1):244-251
pubmed: 30859849

Auteurs

Kristoffer Hendel (K)

Department of Dermatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Anders C N Hansen (ACN)

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Liora Bik (L)

Department of Dermatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Department of Dermatology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

Charlotte Bagger (C)

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Martijn B A van Doorn (MBA)

Department of Dermatology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

Christian Janfelt (C)

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Uffe H Olesen (UH)

Department of Dermatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Merete Haedersdal (M)

Department of Dermatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Catharina M Lerche (CM)

Department of Dermatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH