The Influence of Donor and Recipient Complement C3 Polymorphisms on Liver Transplant Outcome.
Journal
International journal of hepatology
ISSN: 2090-3448
Titre abrégé: Int J Hepatol
Pays: United States
ID NLM: 101564967
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
11
2020
accepted:
27
04
2021
entrez:
14
6
2021
pubmed:
15
6
2021
medline:
15
6
2021
Statut:
epublish
Résumé
Despite early reports of an impact of complement C3 polymorphism on liver transplant patient and graft survival, subsequent evidence has been conflicting. Our aim was to clarify the contributions of donor and recipient C3 genotype, separately and together, on patient and graft outcomes and acute rejection incidence in liver transplant recipients. Eight donor/recipient groups were analyzed according to their genotype and presence or absence of C3 F allele (FFFS, FFSS, FSFF, FSFS, FSSS, SSFF, SSFS, and SSSS) and correlated with clinical outcomes of patient survival, graft survival, and rejection. The further impact of brain death vs. circulatory death during liver donation was also considered. Over a median 5.3 y follow-up of 506 patients with clinical information and matching donor and recipient tissue, five-year patient and graft survival (95% confidence interval) were 90(81-91)% and 77(73-85)%, respectively, and 72(69-94)% were rejection-free. Early disadvantages to patient survival were associated with donor C3 F variant, especially in brain-death donors. Recipient C3 genotype was an independent determinant of graft survival by Cox proportional hazards analysis (hazard ratio 0.26,
Identifiants
pubmed: 34123432
doi: 10.1155/2021/6636456
pmc: PMC8168477
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6636456Informations de copyright
Copyright © 2021 Maria Pires et al.
Déclaration de conflit d'intérêts
The authors of this manuscript have no conflicts of interest to disclose as described by the International Journal of Hepatology.
Références
Mol Immunol. 2007 Jan;44(1-3):57-63
pubmed: 16870256
Blood. 2006 Mar 15;107(6):2461-9
pubmed: 16304047
Nat Med. 2002 Jun;8(6):582-7
pubmed: 12042808
Nephrol Dial Transplant. 1994;9(11):1564-7
pubmed: 7870343
Ann N Y Acad Sci. 1979;332:482-90
pubmed: 394641
N Engl J Med. 2007 Aug 9;357(6):553-61
pubmed: 17634448
N Engl J Med. 1995 Aug 10;333(6):333-6
pubmed: 7609748
Immunol Today. 1983 May;4(5):151-4
pubmed: 25291675
Science. 1969 Jan 17;163(3864):286-8
pubmed: 4883617
Am J Pathol. 2004 Nov;165(5):1677-88
pubmed: 15509537
Kidney Int. 2003 Nov;64(5):1874-82
pubmed: 14531823
Nat Rev Immunol. 2007 Jun;7(6):425-8
pubmed: 17525751
Hum Genet. 1986 Mar;72(3):260-1
pubmed: 3633848
Am J Transplant. 2012 Mar;12(3):660-8
pubmed: 22176838
Transplant Proc. 2001 Feb-Mar;33(1-2):1482-3
pubmed: 11267383
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18995-9000
pubmed: 22065791
J Exp Med. 1990 Oct 1;172(4):1011-7
pubmed: 1976733
J Clin Invest. 1968 Sep;47(9):2181-91
pubmed: 5675433
N Engl J Med. 2009 Feb 26;360(9):874-80
pubmed: 19246358
J Immunol. 1989 Dec 1;143(11):3860-2
pubmed: 2584723
Liver Transpl. 2010 Aug;16(8):943-9
pubmed: 20677285
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8761-6
pubmed: 21555552
Genetics. 2006 Nov;174(3):1695-7
pubmed: 16702429
Blood. 2008 Feb 15;111(4):2452-61
pubmed: 18056835
Am J Transplant. 2017 May;17(5):1255-1266
pubmed: 28199762
Nephrol Dial Transplant. 1987;2(4):208-11
pubmed: 3118258
Nature. 1981 Aug 27;292(5826):840-2
pubmed: 7022223
Biofactors. 1998;8(1-2):161-4
pubmed: 9699026
Nephrol Dial Transplant. 2011 Jul;26(7):2345-54
pubmed: 21127132
J Am Soc Nephrol. 2004 Sep;15(9):2414-22
pubmed: 15339990
Clin Transplant. 2017 Jan;31(1):
pubmed: 27801525
Dis Markers. 1987 Jun;5(2):81-7
pubmed: 3502986
Liver Transpl. 2010 Feb;16(2):198-203
pubmed: 20104494
Curr Opin Immunol. 2003 Oct;15(5):487-92
pubmed: 14499254
Am J Transplant. 2011 Nov;11(11):2279-96
pubmed: 21929642
Nature. 1974 Oct 25;251(5477):740-1
pubmed: 4427677
PLoS One. 2016 Feb 10;11(2):e0148815
pubmed: 26863224
N Engl J Med. 2006 May 11;354(19):2014-23
pubmed: 16687714
Nat Immunol. 2010 Sep;11(9):862-71
pubmed: 20694009
Pathology. 2014 Jan;46(1):1-10
pubmed: 24300728
Clin Transplant. 2005 Aug;19(4):492-500
pubmed: 16008594