The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis.
LRP1
adipocytes
atherosclerosis
endothelial cells
immune cells
macrophages
smooth muscle cells
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
03
2021
accepted:
05
05
2021
entrez:
14
6
2021
pubmed:
15
6
2021
medline:
15
6
2021
Statut:
epublish
Résumé
Low-density lipoprotein receptor-related protein-1 (LRP1) is a large endocytic and signaling receptor belonging to the LDL receptor (LDLR) gene family and that is widely expressed in several tissues. LRP1 comprises a large extracellular domain (ECD; 515 kDa, α chain) and a small intracellular domain (ICD; 85 kDa, β chain). The deletion of LRP1 leads to embryonic lethality in mice, revealing a crucial but yet undefined role in embryogenesis and development. LRP1 has been postulated to participate in numerous diverse physiological and pathological processes ranging from plasma lipoprotein homeostasis, atherosclerosis, tumor evolution, and fibrinolysis to neuronal regeneration and survival. Many studies using cultured cells and
Identifiants
pubmed: 34124208
doi: 10.3389/fcvm.2021.682389
pmc: PMC8192809
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
682389Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Chen, Su, Pi, Hu and Mao.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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