A Robust Mammary Organoid System to Model Lactation and Involution-like Processes.
3D organoid
Ex vivo
Involution
Lactation
Mammary gland
Mouse
Journal
Bio-protocol
ISSN: 2331-8325
Titre abrégé: Bio Protoc
Pays: United States
ID NLM: 101635102
Informations de publication
Date de publication:
20 Apr 2021
20 Apr 2021
Historique:
received:
29
07
2020
revised:
13
01
2021
accepted:
21
01
2021
entrez:
14
6
2021
pubmed:
15
6
2021
medline:
15
6
2021
Statut:
epublish
Résumé
The mammary gland is a highly dynamic tissue that changes throughout reproductive life, including growth during puberty and repetitive cycles of pregnancy and involution. Mammary gland tumors represent the most common cancer diagnosed in women worldwide. Studying the regulatory mechanisms of mammary gland development is essential for understanding how dysregulation can lead to breast cancer initiation and progression. Three-dimensional (3D) mammary organoids offer many exciting possibilities for the study of tissue development and breast cancer. In the present protocol derived from Sumbal et al., we describe a straightforward 3D organoid system for the study of lactation and involution
Identifiants
pubmed: 34124297
doi: 10.21769/BioProtoc.3996
pii: e3996
pmc: PMC8160540
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e3996Informations de copyright
Copyright © 2021 The Authors; exclusive licensee Bio-protocol LLC.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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