Expression Analysis of VDR-Related LncRNAs in Autism Spectrum Disorder.
Autism spectrum disorder
CYP27B1
LINC00511
LncRNA
SNHG6
VDR
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
05
04
2021
accepted:
10
05
2021
pubmed:
15
6
2021
medline:
13
1
2022
entrez:
14
6
2021
Statut:
ppublish
Résumé
Vitamin D receptor (VDR) signaling has been reported to affect neurodevelopment, thus participating in the risk of autism spectrum disorder (ASD). We have measured expression amounts of VDR, CYP27B1, and two related long non-coding RNAs, namely SNHG6 and LINC00511, in the circulation of ASD patients compared with normal controls. Expression of CYP27B1 was remarkably higher in ASD cases compared with controls (posterior beta = 2.38, SE = 0.46, adjusted P value < 0.0001, 95% credible interval (CrI) for beta = [1.49, 3.27]). Level of SNHG6 was lower in ASD cases compared with controls (posterior beta = - 0.791, SE = 0.24, adjusted P value = 0.029, 95% CrI for beta = [- 1.27, - 0.33]). Expression levels of VDR and LINC00511 were similar between ASD cases and controls (P values = 0.97 and 0.46, respectively). Expressions of VDR, CYP27B1, SNHG6, and LINC00511 were not correlated with age of children. However, significant correlations were perceived between expressions of CYP27B1 and LINC00511 (r = 0.47, P < 0.0001), VDR and CYP27B1 (r = 0.42, P < 0.0001), and VDR and SNHG6 (r = 0.32, P < 0.0001). Therefore, these results imply dysregulation of a number of VDR-related genes in ASD patients.
Identifiants
pubmed: 34125396
doi: 10.1007/s12031-021-01858-y
pii: 10.1007/s12031-021-01858-y
doi:
Substances chimiques
RNA, Long Noncoding
0
Receptors, Calcitriol
0
VDR protein, human
0
long non-coding RNA SNHG6, human
0
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
EC 1.14.15.18
CYP27B1 protein, human
EC 1.14.15.18
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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