Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm.
Abdominal aortic aneurysm
inflammation
oxidative stress
phytochemicals.
phytotherapy
plant medicine
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
10
2020
revised:
28
03
2021
accepted:
02
04
2021
pubmed:
16
6
2021
medline:
7
1
2022
entrez:
15
6
2021
Statut:
ppublish
Résumé
Abdominal aortic aneurysms (AAAs) are a leading cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair. This review aimed to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA. In vitro, in vivo, and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised. Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Salvianolic acid as potential treatments for AAA. Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treatments, adequately designed double-blind randomized clinical trials will be required.
Sections du résumé
BACKGROUND
BACKGROUND
Abdominal aortic aneurysms (AAAs) are a leading cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair.
OBJECTIVE
OBJECTIVE
This review aimed to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA.
METHODS
METHODS
In vitro, in vivo, and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised.
RESULTS
RESULTS
Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Salvianolic acid as potential treatments for AAA.
CONCLUSION
CONCLUSIONS
Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treatments, adequately designed double-blind randomized clinical trials will be required.
Identifiants
pubmed: 34126879
pii: CMC-EPUB-116135
doi: 10.2174/0929867328666210614113116
doi:
Substances chimiques
Phytochemicals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8595-8607Informations de copyright
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