1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review.

Antineoplastic Agents / chemical synthesis Cell Proliferation / drug effects Cell Survival / drug effects Drug Screening Assays, Antitumor Humans Molecular Structure Oxadiazoles / chemical synthesis
1 3 4-Oxadiazole Anticancer potential Cancer Pharmacophore. Receptors Synthetic methods

Journal

Current topics in medicinal chemistry
ISSN: 1873-4294
Titre abrégé: Curr Top Med Chem
Pays: United Arab Emirates
ID NLM: 101119673

Informations de publication

Date de publication:
2021
Historique:
received: 19 01 2021
revised: 27 02 2021
accepted: 10 03 2021
pubmed: 16 6 2021
medline: 15 12 2021
entrez: 15 6 2021
Statut: ppublish

Résumé

Cancer is a kind of human cell degenerative disease that has affected many people for several years. Cancer is caused due to the abnormal growth of cells in every particular part of the body. The 1,3,4-oxadiazole ring is found to be a binding moiety that has anticancer potential. Various works on the 1,3,4-oxadiazole moiety showing anticancer activity have been reported. The present analysis summarizes general synthetic methods for 1,3,4 oxadiazole. Different receptors on which these drug acts are discussed. This review also presents pharmacophore models for topoisomerase-I, histone deacetylase, and epidermal growth factor enzymes.

Identifiants

DOI: 10.2174/1568026621666210612031144 PMID: 34126902
pubmed: 34126902
pii: CTMC-EPUB-116117
doi: 10.2174/1568026621666210612031144
doi:

Substances chimiques

Antineoplastic Agents 0
Oxadiazoles 0
1,3,4-oxadiazole 20O2F20OUR

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1377-1397

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Divya Sharma (D)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.
Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Vikas Sharma (V)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Rajnish Kumar (R)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Sagar Joshi (S)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Sunita Kumari (S)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Shivani Saxena (S)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Avijit Mazumder (A)

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, India.

Mohammad Shahar Yar (MS)

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, India.

Mohamed Jawed Ahsan (MJ)

Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Ambabari Circle, Jaipur, Rajasthan- 302039, India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › 1,3,4-Oxadiazoles as Potential Pharmacophore...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › 1,3,4-Oxadiazoles as Potential Pharmacophore...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › 1,3,4-Oxadiazoles as Potential Pharmacophore...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › 1,3,4-Oxadiazoles as Potential Pharmacophore...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 1,3,4-Oxadiazoles as Potential Pharmacophore...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › 1,3,4-Oxadiazoles as Potential Pharmacophore...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Oxadiazoles › 1,3,4-Oxadiazoles as Potential Pharmacophore...