In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer's disease.
Alzheimer Disease
/ diagnosis
Amyloid beta-Peptides
/ analysis
Animals
Cerebral Cortex
/ chemistry
Chlorides
/ administration & dosage
Disease Models, Animal
Female
Humans
Injections, Subcutaneous
Iron
/ analysis
Male
Manganese Compounds
/ administration & dosage
Mice
Mice, Transgenic
Multiparametric Magnetic Resonance Imaging
/ methods
Plaque, Amyloid
/ diagnosis
Rats
Rats, Transgenic
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 06 2021
14 06 2021
Historique:
received:
02
03
2021
accepted:
28
05
2021
entrez:
15
6
2021
pubmed:
16
6
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Amyloid plaques are a hallmark of Alzheimer's disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Animals were given subcutaneous injections of MnCl
Identifiants
pubmed: 34127752
doi: 10.1038/s41598-021-91899-5
pii: 10.1038/s41598-021-91899-5
pmc: PMC8203664
doi:
Substances chimiques
Amyloid beta-Peptides
0
Chlorides
0
Manganese Compounds
0
Iron
E1UOL152H7
manganese chloride
QQE170PANO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12419Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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