Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
08 Jun 2021
08 Jun 2021
Historique:
entrez:
15
6
2021
pubmed:
16
6
2021
medline:
16
6
2021
Statut:
epublish
Résumé
Cardiovascular complications are common in COVID-19 and strongly associated with disease severity and mortality. However, the mechanisms driving cardiac injury and failure in COVID-19 are largely unknown. We performed plasma proteomics on 80 COVID-19 patients and controls, grouped according to disease severity and cardiac involvement. Findings were validated in 305 independent COVID-19 patients and investigated in an animal model. Here we show that senescence-associated secretory proteins, markers of biological aging, strongly associate with disease severity and cardiac involvement even in age-matched cohorts. FSTL3, an indicator of Activin/TGFβ signaling, was the most significantly upregulated protein associated with the heart failure biomarker, NTproBNP (β = 0.4;p
Identifiants
pubmed: 34127963
doi: 10.21203/rs.3.rs-539712/v1
pmc: PMC8202429
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : K76 AG064328
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007208
Pays : United States
Commentaires et corrections
Type : UpdateIn
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