Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.
Journal
Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035
Informations de publication
Date de publication:
08 Jun 2021
08 Jun 2021
Historique:
entrez:
15
6
2021
pubmed:
16
6
2021
medline:
16
6
2021
Statut:
epublish
Résumé
While inhibition of T cell co-inhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. Type 1 interferon (IFN-I) modulates T cell immunity in viral infection, autoimmunity, and cancer, and may facilitate induction of T cell exhaustion in chronic viral infection. Here we show that IFN-I regulates co-inhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while surprisingly inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses enabled the construction of dynamic transcriptional regulatory networks uncovering three temporal transcriptional waves. Perturbation of key transcription factors on human primary T cells revealed unique regulators that control expression of co-inhibitory receptors. We found that the dynamic IFN-I response
Identifiants
pubmed: 34127967
doi: 10.21203/rs.3.rs-133494/v1
pmc: PMC8202434
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA227473
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS045937
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI039671
Pays : United States
Organisme : NINDS NIH HHS
ID : R25 NS079193
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA121974
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089992
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI144166
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI073748
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL145567
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141852
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS030843
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI056299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127349
Pays : United States
Commentaires et corrections
Type : UpdateIn
Références
Nature. 2018 Jun;558(7710):454-459
pubmed: 29899446
Mol Neurobiol. 2017 Sep;54(7):5676-5682
pubmed: 27644129
Cell. 2018 Nov 1;175(4):998-1013.e20
pubmed: 30388456
Gene Ther. 2015 Mar;22(3):227-36
pubmed: 25567537
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
Nat Med. 2010 Oct;16(10):1147-51
pubmed: 20890291
Gene Ther. 2014 Apr;21(4):444-9
pubmed: 24572792
Sci Rep. 2018 Apr 11;8(1):5793
pubmed: 29643425
Nat Med. 2012 Nov;18(11):1682-7
pubmed: 22972397
Immunity. 2016 May 17;44(5):989-1004
pubmed: 27192565
J Clin Invest. 2017 Jan 3;127(1):260-268
pubmed: 27941243
Trends Microbiol. 2017 Jul;25(7):573-584
pubmed: 28139375
Annu Rev Immunol. 2019 Apr 26;37:457-495
pubmed: 30676822
Stat Neerl. 2018 Feb;72(1):4-13
pubmed: 29353942
PLoS Pathog. 2015 Jun 17;11(6):e1004978
pubmed: 26083387
Cell. 2016 Jan 28;164(3):564-78
pubmed: 26824662
J Immunol. 2017 Feb 15;198(4):1484-1491
pubmed: 28093521
Science. 2013 Apr 12;340(6129):207-11
pubmed: 23580529
Genome Biol. 2014;15(12):550
pubmed: 25516281
Science. 2013 Apr 12;340(6129):202-7
pubmed: 23580528
Cell. 2019 Feb 7;176(4):775-789.e18
pubmed: 30595452
Nat Rev Immunol. 2012 Jan 06;12(2):125-35
pubmed: 22222875
Oncoimmunology. 2017 Apr 5;6(5):e1314424
pubmed: 28638743
Nucleic Acids Res. 2013 Jan;41(Database issue):D1040-6
pubmed: 23203888
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
J Clin Invest. 2007 Nov;117(11):3383-92
pubmed: 17932562
Nature. 1997 Dec 11;390(6660):629-32
pubmed: 9403695
Nucleic Acids Res. 2019 Jan 8;47(D1):D100-D105
pubmed: 30445619
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6680-5
pubmed: 11390995
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
J Virol. 2011 Jun;85(12):5929-39
pubmed: 21471240
Clin Rev Allergy Immunol. 2013 Apr;44(2):114-20
pubmed: 22231516
Annu Rev Immunol. 2016 May 20;34:539-73
pubmed: 26927206
J Immunol. 2007 Jun 15;178(12):7607-15
pubmed: 17548596
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Cell Biochem. 2008 Aug 15;104(6):2091-106
pubmed: 18393360
Cell Host Microbe. 2012 Jun 14;11(6):631-42
pubmed: 22704623
J Biopharm Stat. 2017;27(2):308-316
pubmed: 27906607
Nature. 2011 May 25;474(7353):654-7
pubmed: 21613998
Lupus Sci Med. 2019 May 28;6(1):e000336
pubmed: 31205729
PLoS Pathog. 2012 Jan;8(1):e1002352
pubmed: 22241987
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Nat Commun. 2014 May 23;5:3947
pubmed: 24853205
Cell. 2020 Jun 25;181(7):1612-1625.e13
pubmed: 32497499
Cell. 2020 Aug 6;182(3):655-671.e22
pubmed: 32603654
Diagnosis (Berl). 2018 Nov 27;5(4):205-214
pubmed: 30243015
Immunohorizons. 2019 Jan 15;3(1):13-25
pubmed: 31356173
Immunol Rev. 2017 Mar;276(1):97-111
pubmed: 28258697
PLoS One. 2013;8(1):e53095
pubmed: 23349699
Immunity. 2014 Feb 20;40(2):289-302
pubmed: 24530057