TIRADS, SRE and SWE in INDETERMINATE thyroid nodule characterization: Which has better diagnostic performance?
Adult
Aged
Aged, 80 and over
Elasticity Imaging Techniques
Female
Humans
Male
Middle Aged
Preoperative Care
Prospective Studies
ROC Curve
Risk Assessment
/ methods
Sensitivity and Specificity
Severity of Illness Index
Thyroid Gland
/ diagnostic imaging
Thyroid Nodule
/ diagnostic imaging
Thyroidectomy
Ultrasonography
Young Adult
Elastosonography
Shear-wave elastography
Strain-ratio elastography
TIRADS
Thyroid nodule
Journal
La Radiologia medica
ISSN: 1826-6983
Titre abrégé: Radiol Med
Pays: Italy
ID NLM: 0177625
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
30
09
2020
accepted:
20
03
2021
pubmed:
16
6
2021
medline:
27
8
2021
entrez:
15
6
2021
Statut:
ppublish
Résumé
To assess Strain Ratio (SRE) and Shear Wave Elastography (SWE) accuracy alone and with TIRADS classification, for the risk stratification of indeterminate thyroid nodules. 128 Patients with 128 indeterminate nodules candidates for thyroidectomy underwent preoperative staging neck ultrasound and were classified according to K-TIRADS score. After TIRADS evaluation, semi-quantitative (SRE) and quantitative (SWE expressed in kPa) elastosonography were performed and relative diagnostic performances, alone and in combination, were compared through ROC curves analysis. In order to maximize the SRE and SWE sensitivity and specificity, their cut-off values were calculated using the Liu test. Bonferroni test was used to evaluate statistically significant differences with a p value < 0.05. Sensitivity, specificity, PPV and NPV were, respectively, 71.4%, 82.4%, 62.5%, 87.5% for K-TIRADS baseline US, 85.7%, 94.1%, 85.7%, 94.1% for SRE and 57.1%, 79.4%, 53.3%, 81.8% for SWE (kPa expressed). SRE evaluation showed the best diagnostic accuracy compared to the SWE (kPa expressed) (p < 0.05) and to the K-TIRADS (p > 0.05). The association of SRE with conventional ultrasound with K-TIRADS score increased sensitivity (92.9% vs 71.4%) but decreased the specificity than conventional US alone (76.5% vs 82.4%). Strain Elastosonography can be associated with K-TIRADS US examination in the thyroid nodule characterization with indeterminate cytology; in fact, adding the SRE to K-TIRADS assessment significantly increases its sensitivity and negative predictive value. However, further multicenter studies on larger population are warranted.
Identifiants
pubmed: 34129178
doi: 10.1007/s11547-021-01349-5
pii: 10.1007/s11547-021-01349-5
pmc: PMC8370962
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1189-1200Informations de copyright
© 2021. The Author(s).
Références
AJNR Am J Neuroradiol. 1997 Sep;18(8):1423-8
pubmed: 9296181
N Engl J Med. 2012 Aug 23;367(8):705-15
pubmed: 22731672
AJR Am J Roentgenol. 2013 Jun;200(6):1317-26
pubmed: 23701071
J Ultrasound. 2020 Jun;23(2):169-174
pubmed: 32246401
Cytopathology. 2017 Dec;28(6):482-487
pubmed: 29094776
Theranostics. 2017 Mar 7;7(5):1303-1329
pubmed: 28435467
Ultraschall Med. 2019 Aug;40(4):425-453
pubmed: 31238377
Endocr Pract. 2016 May;22(5):622-39
pubmed: 27167915
J Am Coll Radiol. 2017 May;14(5):587-595
pubmed: 28372962
Eur Radiol. 2014 Jan;24(1):143-50
pubmed: 23979108
J Clin Endocrinol Metab. 2019 Jan 1;104(1):95-102
pubmed: 30299457
Thyroid. 2017 Jan;27(1):103-110
pubmed: 27809694
Ultraschall Med. 2015 Apr;36(2):162-7
pubmed: 24955842
Radiol Med. 2019 Feb;124(2):118-125
pubmed: 30244368
J Comput Assist Tomogr. 2008 Sep-Oct;32(5):810-5
pubmed: 18830117
J Ultrasound Med. 2016 Nov;35(11):2397-2404
pubmed: 27794130
Oncotarget. 2017 Jul 25;8(30):49421-49442
pubmed: 28472764
PLoS One. 2012;7(11):e50725
pubmed: 23209819
Endokrynol Pol. 2017;68(6):610-622
pubmed: 29022643
Thyroid. 2017 Nov;27(11):1441-1449
pubmed: 28982296
Endocrine. 2017 Aug;57(2):256-261
pubmed: 27804016
Med Ultrason. 2017 Apr 22;19(2):195-210
pubmed: 28440355
J Laryngol Otol. 2015 Jan;129(1):53-6
pubmed: 25496842
Medicine (Baltimore). 2017 Oct;96(43):e8282
pubmed: 29068996
J Endocrinol Invest. 2014 Jun;37(6):593-9
pubmed: 24789536
Thyroid. 2018 Feb;28(2):210-219
pubmed: 29160163
Cancer Control. 2017 Oct-Dec;24(5):1073274817729231
pubmed: 28975825
J Endocrinol Invest. 2018 Jul;41(7):849-876
pubmed: 29729004
AJR Am J Roentgenol. 2014 Apr;202(4):W379-89
pubmed: 24660737
Arch Surg. 2005 Oct;140(10):981-5
pubmed: 16230549
Radiology. 2015 Nov;277(2):565-73
pubmed: 25955578
J Zhejiang Univ Sci B. 2017 Jul;18(7):555-566
pubmed: 28681580
Ultrasound Med Biol. 2017 Jan;43(1):4-26
pubmed: 27570210
Int J Clin Exp Med. 2015 Sep 15;8(9):15362-72
pubmed: 26629025
Int J Mol Sci. 2017 Apr 12;18(4):
pubmed: 28417935
Eur J Radiol. 2014 Mar;83(3):403-4
pubmed: 23540945
Acta Med Port. 2017 Jun 30;30(6):472-478
pubmed: 28898614
J Ultrasound. 2019 Sep;22(3):315-321
pubmed: 30972642
J Clin Endocrinol Metab. 2020 Sep 1;105(9):
pubmed: 32491169
Eur Thyroid J. 2017 Sep;6(5):225-237
pubmed: 29167761
Thyroid. 2021 Feb;31(2):264-271
pubmed: 32475305
Endocrine. 2019 Mar;63(3):430-438
pubmed: 30519908
Acta Cytol. 2012;56(4):333-9
pubmed: 22846422
Eur Thyroid J. 2014 Sep;3(3):154-63
pubmed: 25538897
J Am Soc Cytopathol. 2017 Nov - Dec;6(6):217-222
pubmed: 31043290
Korean J Radiol. 2016 May-Jun;17(3):370-95
pubmed: 27134526
Ultraschall Med. 2013 Apr;34(2):169-84
pubmed: 23558397
Cytopathology. 2009 Oct;20(5):283-96
pubmed: 19754835
Eur J Radiol. 2015 Apr;84(4):652-61
pubmed: 25638577
Int J Endocrinol. 2017;2017:9692304
pubmed: 28348589
Endocr Connect. 2018 Jan;7(1):1-7
pubmed: 29196301
Radiol Med. 2020 Apr;125(4):406-415
pubmed: 31970579
Med Sci Monit. 2018 Sep 08;24:6273-6279
pubmed: 30194820
J Endocrinol Invest. 2020 Aug;43(8):1115-1123
pubmed: 32100197
Ultrason Imaging. 2017 Sep;39(5):326-336
pubmed: 28468574
J Endocrinol Invest. 2014 Feb;37(2):127-33
pubmed: 24497211
Medicine (Baltimore). 2015 Dec;94(52):e2312
pubmed: 26717367
Endocrine. 2018 Apr;60(1):31-35
pubmed: 28786076