Freshly Thawed Cryobanked Human Neural Stem Cells Engraft within Endogenous Neurogenic Niches and Restore Cognitive Function after Chronic Traumatic Brain Injury.

Animals Biological Specimen Banks Brain Injuries, Traumatic / psychology Brain Injury, Chronic / psychology Cognition / physiology Cryopreservation Disease Models, Animal Humans Male Neural Stem Cells / transplantation Neurogenesis Rats Rats, Nude Stem Cell Niche Stem Cell Transplantation
chronic traumatic brain injury hippocampal neurogenesis human neural stem cells immunomodulation

Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
01 10 2021
Historique:
pubmed: 17 6 2021
medline: 5 3 2022
entrez: 16 6 2021
Statut: ppublish

Résumé

Human neural stem cells (hNSCs) have potential as a cell therapy after traumatic brain injury (TBI). While various studies have demonstrated the efficacy of NSCs from ongoing culture, there is a significant gap in our understanding of freshly thawed cells from cryobanked stocks-a more clinically relevant source. To address these shortfalls, the therapeutic potential of our previously validated Shef-6.0 human embryonic stem cell (hESC)-derived hNSC line was tested after long-term cryostorage and thawing before transplant. Immunodeficient athymic nude rats received a moderate unilateral controlled cortical impact (CCI) injury. At four weeks post-injury, 6

Identifiants

DOI: 10.1089/neu.2021.0045 PMID: 34130484
pubmed: 34130484
doi: 10.1089/neu.2021.0045
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2731-2746

Auteurs

Anna Badner (A)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Emily K Reinhardt (EK)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.

Theodore V Nguyen (TV)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Nicole Midani (N)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Andrew T Marshall (AT)

Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA.

Cherie A Lepe (CA)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Karla Echeverria (K)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Javier J Lepe (JJ)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Vincent Torrecampo (V)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.

Sara H Bertan (SH)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.

Serinee H Tran (SH)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.

Aileen J Anderson (AJ)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
Physical Medicine and Rehabilitation, University of California, Irvine, Irvine, California, USA.
Anatomy and Neurobiology, University of California, Irvine, Irvine, California, USA.

Brian J Cummings (BJ)

Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, California, USA.
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
Physical Medicine and Rehabilitation, University of California, Irvine, Irvine, California, USA.
Anatomy and Neurobiology, University of California, Irvine, Irvine, California, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Biobanques › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Souffrance cérébrale chronique post-traumatique › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Techniques d'investigation › Conservation biologique › Cryoconservation › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Souches mutantes de rat › Rat nude › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Niche de cellules souches › Freshly Thawed Cryobanked Human Neural Stem...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Freshly Thawed Cryobanked Human Neural Stem...